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CNCR seminar
CNCR seminar
Sonja Solovjova
PhD student
Publications
Neuromodulation of Cognition
Complex behaviors that arise in response to stimulus-rich and demanding environments require the coordinated function of different brain circuits at distinct time-scales, to maintain higher-order cognitive functions, such as attention, learning, memory and decision-making. Our main goal is to identify the neuromodulatory forces that mediate these processes, highlighting maladaptations that lead to aberrant cognition.
Danai Riga
Assistant Professor
Léa Dugué
PhD student
CNCR seminar
Tiara Koolman
Technician
Swammerdam
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
CNCR seminar
People
Neurospector
The Neurospector team is dedicated to valorizing scientific knowledge. We aim to accelerate drug development for brain disorders by using predictive human neuron cell models and scalable live microscopy read-outs of neuronal activity.
People
Robin Weiler
PhD student
Su Saka
PhD student
Noémie Zerrouki
PhD student
Jennifer Vlaardingerbroek
Technician
Master internships at CTG
Internship openings for Bachelor students
Internship openings for Master students
Marieke Krepel
PhD student
BRAINSCAPES
MODEM: Mechanisms Of DEMentia
Publications
Molecular & functional specificity of synapses
Synaptic function is tailored for processing distinct types of information in different circuits. The aim of our research is to understand the molecular processes that establish synapse-type-specific functional diversity and plasticity in neuronal networks. Our lab uses a combination of molecular and genetic tools, together with electrophysiology and high-resolution imaging approaches, to study how specializations in synaptic composition influence synaptic transmission properties to drive network function. We are interested in the dynamic molecular interactions that fine-tune synapse organization in different subcellular regions and brain regions, across neurodevelopment and plasticity, and in brain disorders associated with synapse dysfunction.
Pelle Wilbers
PhD student
Angela Getz
Assistant Professor
CNCR Seminar
Extra CNCR seminar
Dorret I Boomsma
Full Professor
Noortje van Geest
PhD student
CNCR seminar
Vasiliki Theodorou
PhD student
CNCR Seminar
Maria Candellero
PhD student
Heiletjé van Zyl
PhD student
CNCR Seminar
Extra CNCR seminar
CNCR Seminar
Cookies
2024
People
Lara Janssen
PhD student
Lisa Geertjens
Clinician
Daniel Puntman
PhD student
Jovana Kovacevic
PhD student
Hanna Lammertse
PhD student
Annemiek van Berkel
PhD student
Hilgo Bruining
Clinician
Mala Misra
Clinician
Mieke van Haelst
Clinician
CNCR Seminar
CNCR Seminar
Seminars
CNCR Seminar
Education
Schooling
Teaching
People
Sebastian Quiroz Monnens
PhD student
Janina Kupke
Postdoctoral researcher
Lotte Smit
Project Manager
Juliette Chevalier
PhD student
Sophie Lee
PhD student
Lotte Rozemeijer
Technician
Tom Cremer
Postdoctoral researcher
Bastian Meth
PhD student
Zeli Chen
PhD student
Julia Kempff
Technician
Cristina Boers Escuder
PhD student
Thomas Blok
PhD student
Femke Waleboer
PhD student
Natia Shamugia
PhD student
Tom Coopmans
PhD student
Tongyu Wang
PhD student
Johana Jarkulischova
PhD student
Galia Polak
PhD student
Marcel Oberlaender
Associate Professor
Marianne Kuin
Technician
Kelsey Ax
Management Support
Ana Carreras Mascaro
Postdoctoral researcher
Vivienne Bauer
PhD student
Thijmen Ligthart
PhD student
Romina Ambrosini Defendi
PhD student
Ambika Mahajan
PhD student
Gerda Berkhout
Management Support
Sara Lozano Seoane
Postdoctoral researcher
Hieke van der Veen
University Research Fellow
Kim Verdaasdonk
PhD student
2023
Sandra Parisi
PhD student
Sanne Beerens
Postdoctoral researcher
Iris van den Heuvel
PhD student
2023
2023
2023
Anastasios Mitsigkolas
Technician
Tjerk Swinkels
PhD student
Miranda Moore
PhD student
Contact
People
Kim de Kleijn
Postdoctoral researcher
Neuro-target discovery group
My group uses screening technology to identify novel, targetable disease mechanisms and biomarkers for neurological disorders. We have set-up genome-wide CRISPR-based screening approaches and use these in combination with cellular model systems to: 1) understand the function of unstudied proteins highly abundant in neurodegenerative disorders, 2) uncover novel disease mechanisms, and 3) identify how disease-related processes in brain cells can be reverted.
Ruud Wijdeven
Study Director
Bart Klein
Technician
Projects
2023
Kim Hubregtse
CNCR PhD coordinator
Contact
Jobs
Publications
People
Neuronal mRNA trafficking and local translation
Neurons are highly polarized and interactive cells that require precise spatiotemporal regulation of their proteins for proper functioning. To achieve this, neurons have the ability to localize mRNAs and locally synthesize proteins. These processes play key roles in the development, plasticity and maintenance of neurons and dysregulation of these processes are increasingly implicated in neurodegenerative diseases. The main focus of my research group is to understand the molecular mechanisms and functional relevance of mRNA trafficking and local translation in neuronal subcellular compartments in health and disease. In particular, we are interested in the role of the endoplasmic reticulum in regulating mRNA localization and local translation and its role in presynaptic function.
Marina Shiryaeva
PhD student
Max Koppers
Assistant Professor
2023
Sascha Koppes
PhD student
Mandy Kater
PhD student
Nicki Covena
PhD student
Lucia Castillo Ransanz
PhD student
Lennert Koomen
Technician
Sylvia Korhorn
Robin Clement
PhD student
Suchita Reddy Enugala
PhD student
Adela Vázquez García
Technician
Stan Driessens
PhD student
Walter Pirovano
Project Manager
Jack Smith
PhD student
Tanya Phung
Postdoctoral researcher
Ana Rita Cunha
PhD student
Loek van der Kallen
Education Director
News
Research teams
People
Synapse Gene Mapping
Together with the SynGO consortium, we are helping to create an expert-curated knowledge database with information about genes expressed in the synapse, their involvement in biological processes and interaction partners. We aim to add information to the database from our own high-throughput molecular experiments. The low amount of false positives will enable us to perform meaningful and reliable pathway analyses that can aid research into synaptopathies such as autism spectrum disorder and schizophrenia. In addition, my team also focuses on innovative ways to maintain the quality of education with a growing student population.
Loek van der Kallen
Education Director
Bernardo de APC Maciel
PhD student
People
Adlin Abramian
PhD student
People
Neurons of human cognition
The main focus of my research is unravelling the cellular basis of human cognition. Traditionally the research on neurobiology of human intelligence focuses on either studying genetic variants associated with intelligence GWAS or imaging of brain areas of intelligence. My ambition is to link these two approaches by studying the function and gene expression in human neurons from neurosurgery in relation to cognition.
Wei Ping Li
PhD student
Marlijn van Baarle
Department Manager
Publications
Robin Clement
PhD student
Panthea Nemat
PhD student
Contact
2022
Jobs
Publications
People
Axon Initial Segment Biology
The axon initial segment is a key compartment in neurons, it is the site of action potential generation. The axon initial segment structure is actively reorganized to accommodate changes in network activity, making this structure an active checkpoint for signal integration. The aim of our research is to unveil the molecular mechanisms controlling axon initial segment plasticity. We want to understand how neurons can adapt to their environment and how this process is altered in neurological disorders.
Amélie Freal
Assistant Professor
2022
Marjo van der Knaap
Full Professor
2022
2022
2022
2022
People
Kevin Marinus
PhD student
Sylvia Korhorn
PhD student
Additya Sharma
PhD student
Clara Hartmann
PhD student
Matthew Vanheusden
PhD student
Almudena Maroto Juanes
PhD student
Iris Kruijff
PhD student
Aiko Robert
PhD student
Contact
Matthew Vanheusden
Events
2021
Ilan Libedinsky
PhD student
Wouter Peyrot
Postdoctoral researcher
Koen Helwegen
PhD student
Marijn Schipper
PhD student
2021
Amparo Roig Adam
PhD student
Jana Hirzinger
PhD student
Li Qianliang
PhD student
Brendan Lodder
Technician
Gerda Berkhout-ter Huurne
Management Support
Judith Huijgen
Technician
News
Neuroticism Summary statistics
Solange Lopes Cardozo
Technician
2021
Lara Janssen
LAVA
LAVA is a tool to conduct genome-wide, local genetic correlation analysis on multiple traits, using GWAS summary statistics as input.
2021
In Silico Brain Sciences
Torben van Voorst
PhD student
Matthieu de Hemptinne
PhD student
Highlights
2021
Vanessa Simões Lourenço
PhD student
Lara Janssen
PhD student
Anna Galakhova
PhD student
Tom Bresser
PhD student
2021
Lisa Geertjens
Rachel Brouwer
Assistant Professor
Pagina niet gevonden
Hilgo Bruining
Dementia Research
Dementia is a major and increasing health problem. Worldwide, 50 million people suffer from dementia and 10 million new cases are diagnosed every year. The most common forms of dementia are Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The progressive cognitive decline associated with AD and FTD presents a huge social and economic burden on our society, and has an immense impact on patients and their families. Dementia is therefore a shared research focus of multiple CNCR teams. Our aim is to identify the pathogenic mechanisms underlying cognitive decline in AD and FTD. We study these mechanisms in models ranging from molecules and cells to animal models and patients. The ultimate goal of our combined research efforts is to contribute to disease modifying therapies and improved early diagnostics for dementia.
People
Dementia Discovery Group
The research in our group focusses on understanding the early cell biological processes that drive Alzheimer’s Disease and other related dementias. We use human stem cell-derived neurons, astrocytes and microglia combined with CRISPR-Cas9 gene-editing to understand how genetic factors drive the earliest stages of disease pathogenesis. We use this knowledge to develop novel drugs for these disorders, with a strong focus on lipid metabolism.
Simon Houtman
2018
2019
2020
News
Miriam Öttl
Theresa Priebe
PhD student
Marina Diachenko
PhD student
Mazyar Abdollahi Nejat
PhD student
Biswajit Moharana
PhD student
Current team members
Team members
Internships
Publications
Femke Roig Kuhn
PhD student
Payam Safavi
PhD student
Annetrude de Mooij
Postdoctoral researcher
Alumni
Molecular Engrams
The main goal of my research team is to identify the bio-molecular framework on which aversive associative memories are built and maintained throughout their lifetime.
2020
Debora Pita Illobre
PhD student
Josse Poppinga
PhD student
Chaimaa Bakali
Technician
Karen Laupman
PhD student
Cato Romero
PhD student
Quinty Bisseling
PhD student
Maaike van Boven
PhD student
Fiona Murphy
PhD student
Jasper Smits
PhD student
Patricia Cheruto Kipkemoi
PhD student
2020
Nathaniel Bell
PhD student
Julia van Adrichem
PhD student
Aline Mak
PhD student
State-dependent processing requires critical brain dynamics
Critical brain dynamics is required for state-dependent processing of stimuli Why do we sometimes hear a quiet sound from across the room, but other times we completely miss someone calling our name when they are standing right next to us? Our perception of the world depends not only on the properties of the stimulus, but also on the current functional state of the brain. Empirical evidence indicates that the amplitude and phase of neuronal oscillations reflect fast-changing functional states with the power to determine whether stimuli are consciously perceived or not; however, it was never studied whether these filtering properties depend on additional mechanisms. A new study shedding light on the pre-requisites for state-dependent responses has been published in eLife jointly led by Arthur-Ervin Avramiea and Richard Hardstone from the Neuronal Oscillations and Cognition group of Klaus Linkenkaer-Hansen (PI in the Department of Integrative Neurophysiology). Here, they used a model of neuronal oscillations (CROS) previously developed in the group, which exhibits a phase-transition from weak short-lived oscillations to strong persistent oscillations as the excitation/inhibition ratio is increased. Poised between these regimes is the “critical point” where excitation and inhibition are in balance, and the current activity carries echoes of past activity tens of seconds in the past, whereas away from the critical point, dependence on past activity is quickly lost. In this study, they show that the ability of networks to regulate stimulus response based on pre-stimulus phase or amplitude requires near-critical dynamics, whereas away from the critical state networks show more stereotyped responses. Thus, the brain may bring its dynamics close to the critical state whenever such network versatility is required, or away from the critical state when more reliable responses are required (e.g., when deeply focused). These results could shed light on conflicting results in the literature where phase-dependent responses are only sometimes observed, and potentially explain sensory or attentional deficits through the inability of the network to reach a certain excitation/inhibition state. Linkenkaer-Hansen adds: “I’m particularly excited about this paper because we show how influential theories of the functional significance of neuronal oscillations implicitly depend on critical brain dynamics. This is yet another confirmation of the broad relevance of the criticality framework that we have developed for more than 20 years”. The study was financed by grants from NWO Exact Sciences and NWO Social Sciences, and is published as: Arthur-Ervin Avramiea*, Richard Hardstone*, Jan-Matthis Lueckmann, Jan Bim, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen. Pre-stimulus phase and amplitude regulation of phase-locked responses are maximized in the critical state. (* Joint First Author) eLife 2020;9:e53016.DOI: https://doi.org/10.7554/eLife.53016 Figure: (A) Critical dynamics of neuronal oscillations occur along the excitation-inhibition balanced regime indicated by the black line. Stimulation experiments show that networks show maximum versatility at criticality as indicated by maximum Dynamic Range (B), as well as maximal pre-stimulus Amplitude (C) and Phase (D) regulation of stimulus responses.
Nicole Breeuwsma
Technician
Roberto Montoro Ferrer
PhD student
Liza Kok
PhD student
Jorin Heijneman
Technician
Christian Lohmann
Endowed professor
Rik van der Kant
Assistant Professor
2020
2020
2020
2020
Ula Bagińska
PhD student
Miriam Öttl
PhD student
Lotte Razenberg
PhD student
Eline Mertens
PhD student
Evangelia Thanou
PhD student
Emil Uffelmann
PhD student
2019
2019
2018
2019
2020
2019
JustforFun
2019
Multivariate GWAS
Use the provided simulation script to compare the Type I error rate and power between multiple multivariate genome-wide association tests.
Douglas Wightman
Postdoctoral researcher
Femke Feringa
Postdoctoral researcher
Irune Guerra San Juan
PhD student
2019
2019
Marta Jorge Oliva
PhD student
Andrea Romaguera Alvarez
PhD student
Jian Dong
PhD student
Lisa Laan
Technician
2019
2018
Suzanne Miedema
PhD student
2018
Mala Misra
Mieke van Haelst
2018
Klaus Linkenkaer-Hansen
Publications
News
People
2018
Connectomics
My research focuses on studying the topological organization of the human brain network, in health and disease. We map and study the human connectome, the ‘road map of the human brain’ and how complex brain function and disfunction may arise from the topological network properties of the human brain network. With my background I bridge psychology, neuroimaging, mathematics, informatics and medicine.
Rory Pijnenburg
PhD student
Siemon de Lange
PhD student
Lianne Scholtens
Postdoctoral researcher
Martijn van den Heuvel
Full Professor
2018
Current internship students
Former internship students
Erika Juárez
PhD student
Marieke Meijer
Daniel Puntman
Niels Cornelisse
2017
Ayoub Khalil
PhD student
2018
test tinca
testt
Lola van Linge
PhD student
Ruud Toonen
Jovana Kovacevic
Genetics behind the disease
Research
Clinical information
Matthijs Verhage
Hanna Lammertse
Annemiek van Berkel
Who are we?
2017
Contact us
STXBP1
2017
Test4
Under construction
STXBP1/Munc18-1 disorders
STXBP-Encephalopathy is a severe genetic disease. We, clinical and fundamental researchers at the VU University in Amsterdam, The Netherlands, work together to better understand STXBP1-E. We aim to improve diagnosis and therapeutic interventions, and to provide (animal and cellular) models to study the disease.
Test
Background – STXBP1 disorder
Projects
Jeanne Savage
Assistant Professor
2017
Jean Pie
PhD student
GWAS Summary Statistics
Download summary statistics from GWAS led by our team here
2017
Jobs
Joris Nassal
PhD student
Kim Wolzak
Postdoctoral researcher
FUMA
Use FUMA for post-GWAS functional annotation of genetic variants
Klinische Genetica Balie
KG-balie: multidisciplinair platform tussen kliniek en research.
News
2013 – 2014
2015 – 2016
2017
SPEC 2017
2016
Night at the Museum
Department of Functional Genomics participates in the Museum Night of Amsterdam at NEMO Science Centre
Brain Myths
Myths about the brain are still everywhere in the 21st century. They can be found in Hollywood movies and self-help books. No matter how popular these ideas about the brain are most of the time they are based on misinterpretations of neuroscientific findings.
Human Brain Project
The HBP aims to put in place a cutting-edge, ICT-based scientific Research Infrastructure for brain research, cognitive neuroscience and brain-inspired computing. The Project promotes collaboration across the globe, and is committed to driving forward European industry.
Research
Internship possibilities
MCN Overview
Overview of MCN teams and their research
About us
Students at work: Anouk de Weger (Leiden University) 2015-2016
Students at work: Esther Visser (UvA) 2015
Cellomics
In recent years genetics studies have uncovered many genes associated to risk for various brain disorders. This brings the challenge to identify the function of a substantial number of these genes in a neuronal context. In particular, robust standardized screening tools are necessary for cellular gene function analysis.*
*
*
High-content screening (HCS), also known as Cellomics, is a microscopy-based method to study gene function or alterations in cellular phenotypes in response to experimental manipulation or treatment.
Dedicated HCS instruments, such as the Cellomics ArrayScan VTI and the Opera LX used by us, allow for high-throughput analysis of cells in 96- or 384-well plates and support unbiased and automated image acquisition and analysis. HCS is therefore particularly useful for high-throughput compound and RNAi screens.*
*
*
To study neurodevelopmental phenotypes we combine HCS with cultured primary embryonic rodent neurons or iPSC-derived human neurons. We perform both RNAi screens and compound screens and have developed a dedicated image analysis pipeline to extract up to 40 HCS parameters associated with neuronal network development and connectivity.
Learning and Memory
MCN teams aim to understand the neurobiological mechanisms of learning and memory.
Projects and Networks
Internships for Bachelor and Master students
2017
Contact
Outreach and Students
The SYNGO Project
The SUN Project
Projects
Contact
Psychiatric disorders
We study depression, substance use disorders (addiction), pathological fear memories and schizophrenia
Neurodegenerative disease
We study dementias, such as Alzheimer's disease and frontal temporal lobe dementia
Synapse biology
At the synapse we strive to understand the function of proteins underlying transmission and plasticity
Education
High-content screening
Priyanka Rao-Ruiz
Assistant Professor
2016
MCN lab 2016
Research
MCN publications
Molecular Mechanisms of Synaptic Plasticity
I aim to mechanistically understand how assemblies of synaptic proteins contribute to synaptic plasticity in health and disease
The Nerve Terminal
Internship projects
Summer School Neurodegeneration
Minor Biomolecular and Neurosciences
Master Neuroscience
Student Internships
Arthur Avramiea
Postdoctoral researcher
Natalia Goriounova
Associate Professor
Josefin Werme
Postdoctoral researcher
Footer
Teaching
Research
About us
2016-2017
University Research Fellowship
Virtual Brain Experience
A virtual reality experience showing how neurons secrete neuropeptides to influence our development, behavior and emotions
Outreach
Information about valorization
Contact
News
Funding
2016
EM facility contact
Here you find the contact information for transmission electron microscopy (TEM) support.
Jobs
News
Publications
People
People Pages
Research Team Pages
Help
Rogier Min
Assistant Professor
Glial (patho)physiology
We study the interactions between neurons and glial cells, both in the healthy brain and in the context of neurological diseases. In particular we focus on the white matter disease MLC, a disease characterized by dysfunctional astrocyte water and ion homeostasis leading to chronic white matter oedema. Our team is embedded in both the VU University medical center (Department of Childhood Neurology headed by Prof. Marjo van der Knaap) and the CNCR (Department of Integrative Neurophysiology headed by Prof. Huibert Mansvelder).
Vision & Cognition
The Vision and Cognition group is led by Pieter Roelfsema, also director of the Netherlands Institute for Neuroscience. Research of this group is directed at understanding cortical mechanisms of visual perception, memory and plasticity. One of our goals is to create a visual cortical prosthesis to restore vision in blind people.
People Pages
Research Team Pages
Help
People
News
Cortical microcircuits
We want to understand how events at the synaptic and cellular levels are involved in behaviour. To reach this goal, we take a multidisciplinary approach in which we combine electrophysiological recordings and imaging from single neurons and networks of neurons with behaviour. By using molecular interventions, optogenetics and assessing the consequences at different levels of organization, we try to get an understanding of the causal relationships between activity of synapses, neurons, neuronal networks, and cognitive behavior. In collaboration with the Neurosurgery department at the VU medical centre, we study the function of human neuronal circuits to test whether basic principles discovered in rodents hold in human cortical microcircuits.
2016
News
People Pages
Research Team Pages
Help
2016
Research Team Pages
Manage people pages
Help page
Publications
Internship
Christina de Veij Mestdagh
PhD student
People
Psychiatric & Statistical Genomics
Research in this group aims at elucidating underlying biological pathways of brain-related traits and translating these to modifiable targets that can aid in treating brain disorders. We integrate knowledge from different fields, including psychiatry, genetics, neuroscience, machine learning, bioinformatics and mathematics.
2016
Stephanie Dooves
Postdoctoral researcher
2014
2015
Events
People
Genoeconomics
Our group investigates how genes influence economic behavior, and how insights into the genetic architecture of behavioral outcomes can inform social and medical research. We use big data, powerful computers, and advanced quantitative methods for our interdisciplinary work.
2015
News INF
Publications
Footer
Research Teams
Footer
People
People
Footer
Footer
2015
News
People
Research Teams
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CTG
Homepage of Complex Trait Genetics Lab
Research Teams
Page not found
Research Teams
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Internship project in bioinformatics
CNCR Seminar Series 2010
CNCR Seminar Series 2016
Teamleader meetings (for teamleaders only)
SPEC 2016
3 PhD-students in cellular neuroscience
SPEC 2015
SPEC 2014
2015
2015
2015
Journal Club
Tuesday Presentations
Vivi Heine
Full Professor
CNCR Seminar Series 2015
Team members
Curated geneSets
Expert curated gene-sets that can be used for gene-set analysis.
SPEC 2011
SPEC 2012
SPEC 2013
SPEC 2010
Earlier
Videos
Prob2plinkbig
Use Prob2plinkbig to convert large MACH probability files to PLINK dosage files.
TATES
Use TATES for multivariate GWAS based on P-values from GWAS.
JAMP
Use JAMP for multivariate GWAS analysis, based on raw genotypic data.
iPSc for Complex Traits
CTGlab hosts the VU stem cell lab to generate iPSC derived nerve cells that can be used to study cellular function important for disease.
Filipa Teixeira Borges
PhD student
Mats Nagel
Postdoctoral researcher
2014
Virtual Brain Experience
Philip Jansen
Postdoctoral researcher
MAGMA
MAGMA is a tool for gene analysis and generalized gene-set analysis of GWAS data. It can be used to analyse both raw genotype data as well as summary SNP p-values from a previous GWAS or meta-analysis.
Cesar Vroom
PhD student
News
Christiaan Levelt
Endowed professor
Former lab members
Pizza Meetings
2014
CNCR Seminar Series 2014
2013
Jobs
Jobs
Jobs
Jobs
Jobs
Jobs
Publications
People
Phenotypic modelling in genetics
While twin- and family studies have shown that many traits are considerably heritable, the role of specific genes in heritable traits remains poorly understood and genes that are identified, only explain a small portion of the trait variance. The focus of this group is on modeling complex and dynamic traits in such a way that the probability to uncover the genetic basis is maximized.
Publications
People
Molecular Neurodegeneration
Alzheimer’s disease (AD) is the most common cause of dementia, however, effective treatment or prevention of the disease is not available to date. The aim of our work is to identify early factors that drive the pathogenesis in sporadic AD. We employ different disease models and post-mortem brain material to investigate molecular pathways leading to AD pathology.
Publications
People
Secretory vesicle trafficking and recycling
My research group aims to uncover the molecular mechanisms involved in membrane trafficking and recycling in synapses at nanometer resolution. We study of the transport, docking and fusion of secretory vesicles and the sorting of critical synaptic proteins through endosomes. Endosome recycling is important for the maintenance of basic neurotransmission, but it is also highly dysregulated in neurogenerative diseases such as Alzheimer’s disease. We aim to understand the causal relation between disease progression and the disruption of the endolysosomal pathway.
Wiep Scheper
Full Professor
Claudia Persoon
Study Director
Masters Internship: Information processing in a neuronal network
Klinische Genetica Balie
2013
Marieke Meijer
Postdoctoral researcher
2013
CNCR Seminar Series 2013
2012
News
Jobs
Internship
JAG
Use JAG for gene-set analysis in GWAS datasets.
Jan van Weering
Assistant Professor
2012
Frank Koopmans
Postdoctoral researcher
Jobs
2012
CNCR Seminar Series 2012
2011
2011
News
Memory Circuits
The goal of my team is to gain mechanistic insight into the neural circuitry, cells and molecules that support persistent memories of negative and positive experiences.
Christiaan de Leeuw
Postdoctoral researcher
2011
Software, Resources & GWAS Sumstats
News
News
News
News
News
News
News
News
News
News
News
News
Vacancy for a Master Thesis project
The Neurophysiological Biomarker Toolbox for research on human brain function
2011
Eus van Someren
Endowed professor
Pieter Roelfsema
Endowed professor
Embedding
Word from the director
Tinca Polderman
Assistant Professor
Books
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
Sophie van der Sluis
Associate Professor
Data Cohorts & Consortia
CTGlab has initiated data collection of two large scale cohorts: NESCOG and ‘BinnensteBuiten’, and is partner in the ID1000 sample collection of the Spinoza Centre, where it is responsible for genetic analyses.
The Genetic Cluster Computer
CTGlab directs the Dutch Genetic Cluster computer, which provides computing power to hundreds of genetic researchers.
Statistical Genetics
Research projects in CTGlab have a strong focus on developing novel statistical tools to benefit from available genomics datasets and aid in detecting genetic pathways underlying disease.
Psychiatric Genetics
A major theme in our group is to understand underlying causes of psychiatric traits.
Imaging Genetics
CTGlab combines brain imaging and genetics to understand how genetic variation in genes or pathways influences cognitive and psychiatric phenotypes by altering brain structure or function.
Genetic and Biological Pathways
Several research projects at CTGlab focus on optimizing methods to define and model the effects of biological pathways on complex traits.
Education
Bachelor and Mastercourses in Genetic neuroscience
Vacancies
News
News items for Complex Trait Genetics Lab
Publications
People
Research
Page not found
Could not find page
2008 – 2009
2005 – 2007
2002 – 2004
CNCR Seminar Series 2011
Publications
Vacancies
Vacancy for PhD position in Glial Regulated Neuronal Plasticity
Yvonne Gouwenberg
Technician
2009
Jaap Timmerman
Technician
Tim Heistek
Technician
2010
Rolinka van der Loo
Technician
Sabine Spijker
Full Professor
Brigitte Borgman
Management Support
Student internships
Search
Braintrain and ONWAR
Our international network
Training Opportunities
A stimulating environment
Joke Wortel
Technician
Ingrid Saarloos
Technician
Robbert Zalm
Technician
Jurjen Broeke
Postdoctoral researcher
Publications
CNCR Seminars
Contact
Joost Verhaagen
Endowed professor
Publications
People
News
Desiree Schut
Technician
Ruud Toonen
Full Professor
Publications
People
Niels Cornelisse
Assistant Professor
Publications
People
Publications
People
Publications
People
Remco Klaassen
PhD student
Ka Wan Li
Assistant Professor
Publications
People
Klaus Linkenkaer-Hansen
Associate Professor
Publications
People
Rien Dekker
Technician
Publications
Mark Verheijen
Associate Professor
Publications
People
Ronald van Kesteren
Full Professor
Publications
Publications
Publications
Michel van den Oever
Associate Professor
Taco de Vries
Full Professor
People
Publications
Christiaan de Kock
Associate Professor
People
Huib Mansvelder
Full Professor
Head of department
2010
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Axon Regeneration
The overall objective of the Laboratory for Neuroregeneration is to unravel the biological mechanisms that govern successful regeneration in the PNS and that underlie degeneration and regenerative failure in the CNS. The primary long-term research objective is to make significant contributions to the field of restorative neuroscience and neurology.
Animal Models of Psychiatric Disease
The focus of my team is on cognition and how it is affected by neuropsychiatric ailments, such as depression. We study maladaptation of synapses and circuitry brought about by unique molecular signatures in hippocampus and prefrontal cortex.
Sleep and Cognition
The Sleep & Cognition group of Eus van Someren and Ysbrand van der Werf works at several locations, including their home base of Netherlands Institute for Neuroscience (KNAW), the VU University (FALW-Integrative Neurophysiology), the VUmc (Dept. Anatomy and Neurosciences) and the Leiden University Medical Center (Sleep Center Leiden). Against the background of their 24-hour rhythm, driven by the circadian clock of the brain, sleep and wakefulness show a mutual dependency.
Psychiatric Etiology
Tinca Polderman has left the CTG lab in April 2020, and works now in Child and Adolescent Psychiatry in Amsterdam. E: tinca.polderman@amsterdamumc.nl
Neuronal Oscillations and Cognition
We aim to understand the role of neuronal oscillations for cognition in health and disease.
Neuroproteomics
My Neuroproteomics team aims to (1) describe the protein complex nano-machinery that underlies synapse function and plasticity, and (2) reveal the alteration of synapse/tissue proteomes in cases of neuro-degenerative and neuropsychiatric disorders. Mass spectrometry based quantitative proteomics analysis is the leading technology behind these studies.
In Vivo Neurophysiology
We study how individual cortical neurons encode sensory stimuli and how sensory representation is affected by behavior. The rodent barrel cortex is an excellent system to study these questions since the individual sensory organs (facial whiskers) are represented by easily identifiable cortical columns. Additionally, our group is part of an international effort to understand human brain function at (sub)cellular resolution.
Dementia Science
Our goal is to understand the specific molecular, cellular and network adaptations that occur in the brain in the earliest stages of Alzheimer’s diseasse, and to test how these adaptations can be used for early disease diagnosis and intervention.
Vesicle Dynamics and Synaptic Plasticity
To process information the brain is constantly changing the strength of individual contacts (synapses) between nerve cells. Strict control of synaptic plasticity is important, as dysregulation of this process is often associated with neurological and psychiatric disorders. The main goal of the lab is to advance our understanding of the mechanisms that support synaptic plasticity and their dysfunction in disorders such as Alzheimer’s, epilepsy, schizophrenia and autism to provide novel treatment options and therapeutic targets.
Glial Regulated Neuronal Plasticity
Our research aims to discover new glial-based mechanisms of information processing in the brain in health and disease, with a focus on the role of astrocytes in the regulation of myelin and synaptic plasticity.
Stem Cell Biology
Although a glial component in neurological disorders is increasingly appreciated, we still lack proper understanding of neuron-glia communications. Our goal is to identify and describe glial defects in neurodevelopmental disorders, and to perform proof-of-concept studies for glial-targeted therapy strategies using advanced stem cell technologies.
Addiction
My aim is to unravel the neurobiological mechanisms underlying drug addiction with a particular focus on relapse mechanisms related to alcohol and nicotine. These studies have a strong multidisciplinary character and include behavioural analysis, proteomics, neurophysiology and opto- and chemogenetic approaches.
Synaptic Computation
Synapses are the basic units of computation in the brain. In my team we study the computational properties of synapses in health and disease. We use physiological- and genetic perturbation experiments and computational modelling in an iterative cycle to study synaptic principles.
2010
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