Selected publications
Kotah JM, Kater MSJ, Brosens N, Lesuis SL, Tandari R, Blok TM, Marchetto L, Yusaf E, Koopmans FTW, Smit AB, Lucassen PJ, Krugers HJ, Verheijen MHG, Korosi A. Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism. Alzheimers Dement. 2023 Dec 6. doi: 10.1002/alz.13569
Kater MSJ, Baumgart KF, Badia-Soteras A, Heistek TS, Carney KE, Timmerman AJ, van Weering JRT, Smit AB, van der Knaap MS, Mansvelder HD, Verheijen MHG, Min R. A novel role for MLC1 in regulating astrocyte-synapse interactions. Glia. 2023 Jul;71(7):1770-1785. doi: 10.1002/glia.24368.
Sophie H Lee, Aline Mak, Mark H G Verheijen. Comparative assessment of the effects of DREADDs and endogenously expressed GPCRs in hippocampal astrocytes on synaptic activity and memory. Front Cell Neurosci. 2023 Mar 27:17:1159756. doi: 10.3389/fncel.2023.1159756.
Mandy S J Kater, Aina Badia-Soteras, Jan R T van Weering, August B Smit, Mark H G Verheijen. Electron microscopy analysis of astrocyte-synapse interactions shows altered dynamics in an Alzheimer’s disease mouse model. Front Cell Neurosci. 2023 Jan 26:17:1085690. doi: 10.3389/fncel.2023.1085690.
Aina Badia-Soteras, Tim S. Heistek, Mandy S.J. Kater, Aline Mak, Adrian Negrean, Michel C. van den Oever, Huibert D. Mansvelder, Baljit S. Khakh, Rogier Min, August B. Smit, Mark H.G. Verheijen. Retraction of astrocyte leaflets from the synapse enhances fear memory. Biological Psychiatry. 2022 https://doi.org/10.1016/j.biopsych.2022.10.013
Kater MSJ, Huffels CFM, Oshima T, Renckens NS, Middeldorp J, Boddeke EWGM, Smit AB, Eggen BJL, Hol EM, Verheijen MHG. Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer’s disease. Brain Behav Immun. 2022 Oct 18;107:225-241.
Sapkota D, Kater MSJ, Sakers K, Nygaard KR, Liu Y, Koester SK, Fass SB, Lake AM, Khazanchi R, Khankan RR, Krawczyk MC, Smit AB, Maloney SE, Verheijen MHG, Zhang Y, Dougherty JD. Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process. Cell Rep. 2022 Oct 18;41(3):111474.
Badia-Soteras A, de Vries J, Dykstra W, Broersen LM, Verkuyl JM, Smit AB, Verheijen MHG. High-Throughput Analysis of Astrocyte Cultures Shows Prevention of Reactive Astrogliosis by the Multi-Nutrient Combination Fortasyn Connect. Cells. 2022 Apr 22;11(9):1428.
Goudriaan A, Loos M, Spijker S, Smit AB, Verheijen MHG. Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice. Cells. 2020 Sep 18;9(9):2119.
Badia-Soteras A, Octeau JC, Verheijen MHG, Khakh BS. Assessing Neuron-Astrocyte Spatial Interactions Using the Neuron-Astrocyte Proximity Assay. Curr Protoc Neurosci. 2020 Mar;91(1):e91. doi: 10.1002/cpns.91.
Abbink MR, van Deijk AF, Heine VM, Verheijen MH, Korosi A.
The involvement of astrocytes in early-life adversity induced programming of the brain. Glia. 2019 Sep;67(9):1637-1653. doi: 10.1002/glia.23625.
Oosterhof N, Kuil LE, van der Linde HC, Burm SM, Berdowski W, van Ijcken WFJ, van Swieten JC, Hol EM, Verheijen MHG, van Ham TJ. Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Rep. 2018 Jul 31;24(5):1203-1217.
van Deijk AF, Broersen LM, Verkuyl JM, Smit AB, Verheijen MHG. High Content Analysis of Hippocampal Neuron-Astrocyte Co-cultures Shows a Positive Effect of Fortasyn Connect on Neuronal Survival and Postsynaptic Maturation.
Front Neurosci. 2017 Aug 4;11:440.
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG. Oligodendroglial myelination requires astrocyte-derived lipids. PLoS Biol. 2017; 26;15(5):e1002605
van Deijk AF, Camargo N, Timmerman J, Heistek T, Brouwers JF, Mogavero F, Mansvelder HD, Smit AB, Verheijen MH. 2017. Astrocyte lipid metabolism is critical for synapse development and function in vivo. Glia. 2017; 65(4):670-682
Eising E, de Leeuw C, Min JL, Anttila V, Verheijen MH, Terwindt GM, Dichgans M, Freilinger T, Kubisch C; International Headache Genetics Consortium, Ferrari MD, Smit AB, de Vries B, Palotie A, van den Maagdenberg AM, Posthuma D. Involvement of astrocyte and oligodendrocyte gene sets in migraine. Cephalalgia. 2016; 36(7):640-7.
Chavarria-Siles I, White T, de Leeuw C, Goudriaan A, Lips E, Ehrlich S, Turner JA, Calhoun VD, Gollub RL, Magnotta VA, Ho BC, Smit AB, Verheijen MH, Posthuma D. Myelination-related genes are associated with decreased white matter integrity in schizophrenia. Eur J Hum Genet. 2016; 24(3):381-386
de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM; Tourette Syndrome Association International Consortium for Genetics, Verheijen MH, Posthuma D. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. Eur J Hum Genet. 2015; 23(11):1519-1522.
Rao-Ruiz P, Carney KE, Pandya N, van der Loo RJ, Verheijen MH, van Nierop P, Smit AB, Spijker S. Time-dependent changes in the mouse hippocampal synaptic membrane proteome after contextual fear conditioning. Hippocampus. 2015; 25(11):1250-61
Carney KE, Milanese M, van Nierop P, Li KW, Oliet SH, Smit AB, Bonanno G, Verheijen MH. Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins. J Proteome Res 2014; 13(12):5918-27.
Goudriaan A, Camargo N, Carney KE, Oliet SH, Smit AB, Verheijen MH. Novel cell separation method for molecular analysis of neuron-astrocyte co-cultures. Front Cell Neurosci. 2014; 30;8:12.
Goudriaan A, de Leeuw C, Ripke S, Hultman CM, Sklar P, Sullivan PF, Smit AB, Posthuma D, Verheijen MH. Specific glial functions contribute to schizophrenia susceptibility. Schizophr Bull. 2014; 40(4):925-35.
Camargo N, Brouwers JF, Loos M, Gutmann DH, Smit AB, Verheijen MH. High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism. FASEB J. 2012; 26(10):4302-15
Verdier, V., Csardi, G., de Preux-Charles, A.S., Medard, J.J., Smit, A.B., Verheijen, M.H., Bergmann, S., and Chrast, R. Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways. *Glia. 2012; 60(5): 751-760.
Chrast, R., Saher, G., Nave, K.A., and Verheijen, M.H. Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models. Journal of lipid research, 2011; 52(3): 419-434.
Verheijen, M.H., Lammens, M., Ceuterick-de Groote, C., Timmerman, V., De Jonghe, P., King, R.H., Smit, A.B., and van Minnen, J. Increased axonal ribosome numbers in CMT diseases. J Peripher Nerv Syst 2011; 16(1): 71-73.
Verheijen, M.H., Camargo, N., Verdier, V., Nadra, K., de Preux Charles, A.S., Medard, J.J., Luoma, A., Crowther, M., Inouye, H., Shimano, H., Chen, S., Brouwers, J.F., Helms, J.B., Feltri, M.L., Wrabetz, L., Kirschner, D., Chrast, R., and Smit, A.B. SCAP is required for timely and proper myelin membrane synthesis. Proceedings of the National Academy of Sciences of the United States of America 2009; 106(50): 21383-21388.
Camargo, N., Smit, A.B., and Verheijen, M.H. SREBPs: SREBP function in glia-neuron interactions. The FEBS journal. 2009; 276(3): 628-636.
Nadra, K., de Preux Charles, A.S., Medard, J.J., Hendriks, W.T., Han, G.S., Gres, S., Carman, G.M., Saulnier-Blache, J.S., Verheijen, M.H., and Chrast, R. Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes Dev 2008; 22(12): 1647-1661.
de Preux, A.S., Goosen, K., Zhang, W., Sima, A.A., Shimano, H., Ouwens, D.M., Diamant, M., Hillebrands, J.L., Rozing, J., Lemke, G., Beckmann, J.S., Smit, A.B., Verheijen, M.H., and Chrast, R. SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status. Molecular and cellular neurosciences. 2007; 35(4): 525-534.
Chrast, R., Verheijen, M.H., and Lemke, G. Complement factors in adult peripheral nerve: a potential role in energy metabolism. Neurochem Int. 2004; 45(2-3): 353-359.
Senderek, J., Bergmann, C., Stendel, C., Kirfel, J., Verpoorten, N., De Jonghe, P., Timmerman, V., Chrast, R., M, H.G.V., Lemke, G., Battaloglu, E., Parman, Y., Erdem, S., Tan, E., Topaloglu, H., Hahn, A., Muller-Felber, W., Rizzuto, N., Fabrizi, G.M., Stuhrmann, M., Rudnik-Schoneborn, S., Zuchner, S., Michael Schroder, J., Buchheim, E., Straub, V., Klepper, J., Huehne, K., Rautenstrauss, B., Buttner, R., Nelis, E., and Zerres, K. Mutations in a Gene Encoding a Novel SH3/TPR Domain Protein Cause Autosomal Recessive Charcot-Marie-Tooth Type 4C Neuropathy. American journal of human genetics. 2003; 73(6): 1106-1119.
Zhu, D., Kennerson, M., Merory, J., Chrast, R., Verheijen, M., Lemke, G., and Nicholson, G. Refined localization of dominant intermediate Charcot-Marie-Tooth neuropathy and exclusion of seven known candidate genes in the region. Neurogenetics 2003; 4(4): 179-183.
Verheijen, M.H., Chrast, R., Burrola, P., and Lemke, G. Local regulation of fat metabolism in peripheral nerves. Genes Dev 2003; 17(19): 2450-2464.