Lucia Castillo Ransanz

PhD student

Contact info

  • Address

    Vrije Universiteit Amsterdam
    Center for Neurogenomics and Cognitive Research (CNCR)
    Department of Complex Trait Genetics
    W&N building, G3
    De Boelelaan 1085
    1081 HV Amsterdam
    The Netherlands

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Short CV

2022 – present PhD candidate Vrije Universiteit Amsterdam
2019 – 2021 Master in Neuroscience (cum laude) Vrije Universiteit Amsterdam
2018 – 2019 Master in Genetics and Molecular Biology UAH, UAM and UCM, Madrid Spain
2014 – 2018 Bachelor in Health Biology UAH, Madrid Spain


Neural cells are continuously exposed to mechanical cues that arise from their microenvironment, such as topography, stiffness and viscoelasticity. Recent research has proven the relevance of mechanical cues during brain development and normal brain function, highlighting their role in processes such as neural migration, proliferation, or differentiation. Furthermore, numerous studies have revealed the involvement of mechano-related signalling pathways on several neurological diseases, such as Tuberous Sclerosis Complex, a genetic multisystem disorder with neurological manifestations. Nevertheless, most of the current cell culture systems do not integrate the mechanical aspects of neural microenvironment, stressing the need to develop in vitro culture platforms that include these parameters. My work explores the combination of iPSC technology and 3D printing techniques to increase the physiological relevance of in vitro brain models and study TSC disease mechanisms from a mechanobiological perspective.

Highlighted publications