Lianne Scholtens

Team Member

Contact info

  • Address

    Vrije Universiteit Amsterdam
    Center for Neurogenomics and Cognitive Research (CNCR)
    Department of Complex Trait Genetics
    W&N building, Room B-636
    De Boelelaan 1085
    1081 HV Amsterdam
    The Netherlands

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Profile image of Lianne Scholtens

Short CV

2018-present Postdoctoral researcher VU University
2017-2018 Postdoctoral researcher University Medical Center Utrecht
2013-2018 PhD candidate University Medical Center Utrecht
2010-2012 MSc Cognitive Neuroscience Radboud University Nijmegen
2007-2010 BSc Biology Radboud University Nijmegen


The mammalian brain is a highly complex organ, with a broad range of regional microscale cellular morphologies and macroscale global properties, together forming an efficient system for processing and integration of multimodal information. Scientists investigating the brain across different species and across scales of observation have reported on a large regional variability in brain organization, both on the microscale of cortical structure as well as in the macroscale of corticocortical connectivity. My work explores the association between whole-brain patterns of microscale architecture and macroscale region-to-region connectivity.

Highlighted publications

Scholtens LH, van den Heuvel MP (2018) Multimodal connectomics in psychiatry: bridging
scales from micro to macro. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging.

Collin G, Scholtens LH, Kahn RS, Hillegers MH, van den Heuvel MP (2017) Affected anatomical rich club and structural-functional coupling in young offspring of schizophrenia and bipolar disorder patients. Biological Psychiatry 82:746–755.

Scholtens LH, de Reus MA, de Lange SC, Schmidt R, van den Heuvel MP (2016) An MRI Von Economo – Koskinas atlas. NeuroImage epub Dec 28.

Turk* E, Scholtens LH *, van den Heuvel MP (2016) Cortical chemoarchitecture shapes macroscale effective functional connectivity patterns in macaque cerebral cortex. Human Brain Mapping 37:1856–1865.

van den Heuvel MP, Scholtens LH, Turk E, Mantini D, Vanduffel W, Feldman Barrett L (2016) Multimodal analysis of cortical chemoarchitecture and macroscale fmri resting-state functional connectivity. Human Brain Mapping 37:3103–3113.

Scholtens LH, de Reus MA, van den Heuvel MP (2015) Linking contemporary high resolution magnetic resonance imaging to the von economo legacy: A study on the comparison of MRI cortical thickness and histological measurements of cortical structure. Human Brain Mapping 36:3038–3046.

Marqués-Iturria I, Scholtens LH, Garolera M, Pueyo R, García-García I, González-Tartiere P, Segura B, Junqué C, Sender-Palacios M, Vernet-Vernet M et al. (2015) Affected connectivity organization of the reward system structure in obesity. NeuroImage 111:100–106.

van den Heuvel MP, Scholtens LH, de Reus MA, Kahn RS (2015) Associated microscale spine density and macroscale connectivity disruptions in schizophrenia. Biological Psychiatry 80:293– 301.

van den Heuvel MP, Scholtens LH, Barrett LF, Hilgetag CC, de Reus MA (2015) Bridging cytoarchitectonics and connectomics in human cerebral cortex. The Journal of Neuroscience35:13943–13948.

van den Heuvel MP, Scholtens LH, de Reus MA (2015) Topological organization of connectivity strength in the rat connectome. Brain Structure and Function pp. 1–18.

van den Heuvel MP, de Reus MA, Feldman Barrett L, Scholtens LH, Coopmans FM, Schmidt R, Preuss TM, Rilling JK, Li L (2015) Comparison of diffusion tractography and tract- tracing measures of connectivity strength in rhesus macaque connectome. Human brain mapping 36: 3064-3075.

Scholtens LH, Schmidt R, de Reus MA, van den Heuvel MP (2014) Linking macroscale graph analytical organization to microscale neuroarchitectonics in the macaque connectome. The Journal of Neuroscience 34:12192–12205.