Roberto Montoro Ferrer

PhD student

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Short CV

2019-present PhD candidate Amsterdam UMC
2017-2019 Master of Science in Neuroscience Erasmus University Rotterdam
2014-2017 Biotechnology degree Universidad Católica de Valencia


Adrenoleukodystrophy (ALD) is the most common peroxisomal disorder distinguished by a spectrum of progressive neurodegenerative outcomes affecting the white matter. ALD is characterized by deficiencies in ABCD1, which result in accumulation of very long-chain fatty acids (VLCFAs) in tissues and plasma and impairment of peroxisomal VLCFA -oxidation. The role of VLCFAs in the pathogenesis of ALD and how its accumulation eventually leads to the loss of myelin in patients remains unknown. Animal models do not fully recapitulate the disease pathophysiology. Therefore, the aim of my PhD project is to generate an in vitro organoid model of ALD using iPSCs derived from ALD patients to decipher its underlying neuropathogenesis.

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