Dementia is a major and increasing health problem. Worldwide, 50 million people suffer from dementia and 10 million new cases are diagnosed every year. The most common forms of dementia are Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The progressive cognitive decline associated with AD and FTD presents a huge social and economic burden on our society, and has an immense impact on patients and their families. Dementia is therefore a shared research focus of multiple CNCR teams. Our aim is to identify the pathogenic mechanisms underlying cognitive decline in AD and FTD. We study these mechanisms in models ranging from molecules and cells to animal models and patients. The ultimate goal of our combined research efforts is to contribute to disease modifying therapies and improved early diagnostics for dementia.