Somatic Tardbp Variants as Cause of Semantic Dementia.
J Van Rooij, M Mol, S Melhem, P van der Wal, P Arp, F Paron, L Donker Kaat, H Seelaar, NB Bank, SSM Miedema, A Uitterlinden, J van Meurs, RE van Kesteren, S A.B., E Buratti, and JC van Swieten
Brain doi:10.1093/brain/awaa317 (2020)
Hyperexcitable Pv Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta.
S Hijazi, TS Heistek, R van der Loo, HD Mansvelder, AB Smit, and RE van Kesteren
iScience doi:10.1016/j.isci.2020.101271 (2020)
Endoplasmic Reticulum Stress Actively Suppresses Hepatic Molecular Identity in Damaged Liver.
V Dubois, C Gheeraert, W Vankrunkelsven, J Dubois-Chevalier, H Dehondt, M Bobowski-Gerard, M Vinod, FP Zummo, F Guiza, M Ploton, E Dorchies, L Pineau, A Boulinguiez, E Vallez, E Woitrain, E Bauge, F Lalloyer, C Duhem, N Rabhi, RE van Kesteren, CM Chiang, S Lancel, H Duez, JS Annicotte, R Paumelle, I Vanhorebeek, G Van den Berghe, B Staels, P Lefebvre, and J Eeckhoute
Mol. Syst. Biol. 16:e9156 (2020)
Combined Cellomics and Proteomics Analysis Reveals Shared Neuronal Morphology and Molecular Pathway Phenotypes for Multiple Schizophrenia Risk Genes.
M Rosato, S Stringer, T Gebuis, I Paliukhovich, KW Li, D Posthuma, PF Sullivan, AB Smit, and RE van Kesteren
Mol. Psychiatry doi:10.1038/s41380-019-0436-y (2019)
Early Restoration of Parvalbumin Interneuron Activity Prevents Memory Loss and Network Hyperexcitability in a Mouse Model of Alzheimer’s Disease.
S Hijazi, TS Heistek, P Scheltens, U Neumann, DR Shimshek, HD Mansvelder, AB Smit, and RE van Kesteren
Mol. Psychiatry doi:10.1038/s41380-019-0483-4 (2019)
Multi-Level Characterization of Balanced Inhibitory-Excitatory Cortical Neuron Network Derived from Human Pluripotent Stem Cells.
AG Nadadhur, J Emperador Melero, M Meijer, D Schut, G Jacobs, KW Li, JJJ Hjorth, RM Meredith, RF Toonen, RE Van Kesteren, AB Smit, M Verhage, and VM Heine
PLoS One 12:e0178533 (2017)
Repulsive Guidance Molecule a (Rgma) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson’s Disease.
JA Korecka, EB Moloney, R Eggers, B Hobo, S Scheffer, N Ras-Verloop, RJ Pasterkamp, DF Swaab, AB Smit, RE van Kesteren, K Bossers, and J Verhaagen
J. Neurosci. 37:9361-9379 (2017)
Dynamics of the Mouse Brain Cortical Synaptic Proteome During Postnatal Brain Development.
MA Gonzalez-Lozano, P Klemmer, T Gebuis, C Hassan, P van Nierop, RE van Kesteren, AB Smit, and KW Li
Sci Rep 6:35456 (2016)
Progression and Recovery of Parkinsonism in a Chronic Progressive Mptp-Induction Model in the Marmoset without Persistent Molecular and Cellular Damage.
SK Franke, RE Van Kesteren, JAM Wubben, S Hofman, I Paliukhovich, RC Van Der Schors, P van Nierop, AB Smit, and IHCHM Philippens
Neuroscience 312:247-259 (2016)
Individual and Familial Susceptibility to Mptp in a Common Marmoset Model for Parkinson’s Disease.
SK Franke, RE van Kesteren, S Hofman, JAM Wubben, AB Smit, and IHCHM Philippens
Neurodegenerative Dis 16:1-11 (2016)
Genetic Deletion of the Transcriptional Repressor Nfil3 Enhances Axon Growth in Vitro but Not Axonal Repair in Vivo.
LR van der Kallen, R Eggers, EM Ehlert, J Verhaagen, AB Smit, and RE van Kesteren
PLoS ONE 10:e0127163 (2015)
Ubiquitin Ligase Trim3 Controls Hippocampal Plasticity and Learning by Regulating Synaptic Gamma-Actin Levels.
J Schreiber, MJ Vegh, J Dawitz, T Kroon, M Loos, D Labonté, KW Li, P van Nierop, MT Van Diepen, CI De Zeeuw, M Kneussel, RM Meredith, AB Smit, and RE van Kesteren
J Cell Biol 211:569-586 (2015)
Tripeptidyl Peptidase Ii Mediates Levels of Nuclear Phosphorylated Erk1 and Erk2.
A Wiemhoefer, A Stargardt, WA van der Linden, MC Renner, RE van Kesteren, J Stap, MA Raspe, B Tomkinson, HW Kessels, H Ovaa, HS Overkleeft, B Florea, and EA Reits
Mol Cell Proteomics 14:2177-2193 (2015)
Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson&Apos;S Disease.
AA Dijkstra, A Ingrassia, RX de Menezes, RE van Kesteren, AJM Rozemuller, P Heutink, and WDJ van de Berg
PLoS ONE 10:e0128651 (2015)
Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-Dependent Cognitive Decline.
MJ Vegh, A Rausell, M Loos, CM Heldring, W Jurkowski, P van Nierop, I Paliukhovich, KW Li, A del Sol, AB Smit, S Spijker, and RE van Kesteren
Mol Cell Proteomics 13:2975-2985 (2014)
Reducing Hippocampal Extracellular Matrix Reverses Early Memory Deficits in a Mouse Model of Alzheimer’s Disease.
MJ Vegh, CM Heldring, W Kamphuis, S Hijazi, AJ Timmerman, KW Li, P van Nierop, HD Mansvelder, EM Hol, AB Smit, and RE van Kesteren
Acta Neuropathol Comm 2:76 (2014)
A Multilevel Screening Strategy Defines a Molecular Fingerprint of Proregenerative Olfactory Ensheathing Cells and Identifies Scarb2, a Protein That Improves Regenerative Sprouting of Injured Sensory Spinal Axons.
KCD Roet, EHP Franssen, FM de Bree, AHW Essing, S-JJ Zijlstra, ND Fagoe, HM Eggink, R Eggers, AB Smit, RE van Kesteren, and J Verhaagen
J Neurosci 33:11116-11135 (2013)
Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.
TS Rizzi, S Van Der Sluis, C Derom, E Thiery, RE van Kesteren, N Jacobs, S Van Gestel, R Vlietinck, M Verhage, P Heutink, and D Posthuma
PLoS ONE 8:e68000 (2013)
Trim3 Regulates the Motility of the Kinesin Motor Protein Kif21b.
D Labonté, E Thies, Y Pechmann, AJ Groffen, M Verhage, AB Smit, RE van Kesteren, and M Kneussel
PLoS ONE 8:e75603 (2013)
Phenotypic Characterization of Retinoic Acid Differentiated Sh-Sy5y Cells by Transcriptional Profiling.
JA Korecka, RE van Kesteren, E Blaas, SO Spitzer, JH Kamstra, AB Smit, DF Swaab, J Verhaagen, and K Bossers
PLoS ONE 8:e63862 (2013)
High Content Screening in Neurodegenerative Diseases.
S Jain, RE van Kesteren, and P Heutink
J Vis Exp e3452 (2012)
Synaptic Proteome Changes in a DNA Repair Deficient Ercc1 Mouse Model of Accelerated Aging.
MJ Vegh, MC de Waard, I van der Pluijm, Y Ridwan, MJM Sassen, P van Nierop, RC van der Schors, KW Li, JHJ Hoeijmakers, AB Smit, and RE van Kesteren
J Proteome Res 11:1855-1867 (2012)
Identification of Context-Specific Gene Regulatory Networks with Gemula—Gene Expression Modeling Using Lasso.
G Geeven, RE van Kesteren, AB Smit, and MCM De Gunst
Bioinformatics 28:214-221 (2012)
Molecular Target Discovery for Neural Repair in the Functional Genomics Era.
J Verhaagen, RE van Kesteren, KAM Bossers, HD Macgillavry, MR Mason, and AB Smit
Spinal Cord Injury 109:595-616 (2012)
Defective Glial Maturation in Vanishing White Matter Disease.
M Bugiani, I Boor, B van Kollenburg, N Postma, E Polder, C van Berkel, RE van Kesteren, MS Windrem, EM Hol, GC Scheper, SA Goldman, and MS van der Knaap
J Neuropathol Exp Neurol 70:69-82 (2011)
LLM3D: A Log-Linear Modeling-Based Method to Predict Functional Gene Regulatory Interactions from Genome-Wide Expression Data.
G Geeven, HD Macgillavry, R Eggers, MM Sassen, J Verhaagen, AB Smit, MCM De Gunst, and RE van Kesteren
Nucleic Acids Res 39:5313-5327 (2011)
Caltubin, a Novel Molluscan Tubulin-Interacting Protein, Promotes Axonal Growth and Attenuates Axonal Degeneration of Rodent Neurons.
N Nejatbakhsh, C-H Guo, TZ Lu, L Pei, AB Smit, H-S Sun, RE van Kesteren, and Z-P Feng
J Neurosci 31:15231-15244 (2011)
Genome-Wide Gene Expression and Promoter Binding Analysis Identifies Nfil3 as a Repressor of C/Ebp Target Genes in Neuronal Outgrowth.
HD Macgillavry, J Cornelis, LR van der Kallen, MM Sassen, J Verhaagen, AB Smit, and RE van Kesteren
Mol Cell Neurosci 46:460-468 (2011)
A Gene Network Perspective on Axonal Regeneration.
RE van Kesteren, MRJ Mason, HD Macgillavry, AB Smit, and J Verhaagen
Front Mol Neurosci 4:46 (2011)
Nfil3 and Camp Response Element-Binding Protein Form a Transcriptional Feedforward Loop That Controls Neuronal Regeneration-Associated Gene Expression.
HD Macgillavry, FJ Stam, MM Sassen, L Kegel, WTJ Hendriks, J Verhaagen, AB Smit, and RE van Kesteren
J Neurosci 29:15542-15550 (2009)
Transcriptome Analysis of the Central Nervous System of the Mollusc Lymnaea Stagnalis.
Z-P Feng, Z Zhang, RE Van Kesteren, VA Straub, P van Nierop, K Jin, N Nejatbakhsh, JI Goldberg, GE Spencer, MS Yeoman, W Wildering, JR Coorssen, RP Croll, LT Buck, NI Syed, and AB Smit
BMC Genomics 10:451 (2009)
Postsynaptic Expression of an Epidermal Growth Factor Receptor Regulates Cholinergic Synapse Formation between Identified Molluscan Neurons.
RE van Kesteren, JS Gagatek, A Hagendorf, Y Gouwenberg, AB Smit, and NI Syed
Eur J Neurosci 27:2043-2056 (2008)
Identification of Candidate Transcriptional Modulators Involved in Successful Regeneration after Nerve Injury.
FJ Stam, HD Macgillavry, NJ Armstrong, MCM De Gunst, Y Zhang, RE van Kesteren, AB Smit, and J Verhaagen
Eur J Neurosci 25:3629-3637 (2007)
Local Synthesis of Actin-Binding Protein Beta-Thymosin Regulates Neurite Outgrowth.
RE van Kesteren, C Carter, HMG Dissel, J van Minnen, Y Gouwenberg, NI Syed, GE Spencer, and AB Smit
J Neurosci 26:152-157 (2006)
Lfrfamides: A Novel Family of Parasitation-Induced -Rfamide Neuropeptides That Inhibit the Activity of Neuroendocrine Cells in Lymnaea Stagnalis.
RM Hoek, KW Li, J van Minnen, JC Lodder, M De Jong-Brink, AB Smit, and RE Van Kesteren
J Neurochem 92:1073-1080 (2005)
Differential Gabaa Receptor Clustering Determines Gaba Synapse Plasticity in Rat Oxytocin Neurons around Parturition and the Onset of Lactation.
J-J Koksma, J-M Fritschy, V Mack, RE van Kesteren, and AB Brussaard
Mol Cell Neurosci 28:128-140 (2005)
The Molluscan Ring-Finger Protein L-Trim Is Essential for Neuronal Outgrowth.
MT Van Diepen, GE Spencer, J van Minnen, Y Gouwenberg, J Bouwman, AB Smit, and RE Van Kesteren
Mol Cell Neurosci 29:74-81 (2005)
Characterization of a Novel Molluskan Tyrosine Kinase Receptor That Inhibits Neurite Regeneration.
J Hislop, JR Dyer, D Scott, RE van Kesteren, and WS Sossin
J Neurobiol 60:127-136 (2004)
Granularin, a Novel Molluscan Opsonin Comprising a Single Vwf Type C Domain Is up-Regulated During Parasitation.
AB Smit, M De Jong-Brink, KW Li, MMJ Sassen, S Spijker, R Van Elk, S Buijs, J van Minnen, and RE van Kesteren
FASEB J 18:845-847 (2004)
The Role of Neurotransmitters in Neurite Outgrowth and Synapse Formation.
RE van Kesteren, and GE Spencer
Rev Neurosci 14:217-231 (2003)
Oxytocin Regulates Neurosteroid Modulation of Gaba(a) Receptors in Supraoptic Nucleus around Parturition.
J-J Koksma, RE van Kesteren, TW Rosahl, R Zwart, AB Smit, H Luddens, and AB Brussaard
J Neurosci 23:788-797 (2003)
Peptidergic Modulation of Male Sexual Behavior in Lymnaea Stagnalis: Structural and Functional Characterization of -Fvamide Neuropeptides.
AB Smit, RE Van Kesteren, S Spijker, J van Minnen, FA Van Golen, CR Jimenez, and KW Li
J Neurochem 87:1245-1254 (2003)
Synapse Formation between Central Neurons Requires Postsynaptic Expression of the Men1 Tumor Suppressor Gene.
RE Van Kesteren, NI Syed, DW Munno, J Bouwman, Z-P Feng, WP Geraerts, and AB Smit
J Neurosci 21:RC161 (2001)
Functional Implications of Neurotransmitter Expression During Axonal Regeneration: Serotonin, but Not Peptides, Auto-Regulate Axon Growth of an Identified Central Neuron.
CE Koert, GE Spencer, J van Minnen, KW Li, WP Geraerts, NI Syed, AB Smit, and RE Van Kesteren
J Neurosci 21:5597-5606 (2001)
Neurotrophic Actions of a Novel Molluscan Epidermal Growth Factor.
PM Hermann, RE Van Kesteren, WC Wildering, SD Painter, JM Reno, JS Smith, SB Kumar, WP Geraerts, LH Ericsson, AB Smit, AG Bulloch, and GT Nagle
J Neurosci 20:6355-6364 (2000)
Early Evolutionary Origin of the Neurotrophin Receptor Family.
RE Van Kesteren, M Fainzilber, G Hauser, J van Minnen, E Vreugdenhil, AB Smit, CF Ibanez, WP Geraerts, and AG Bulloch
EMBO J 17:2534-2542 (1998)
Molecular Evolution of Ligand-Binding Specificity in the Vasopressin/Oxytocin Receptor Family.
RE Van Kesteren, and WP Geraerts
Ann N Y Acad Sci 839:25-34 (1998)
Towards Understanding the Role of Insulin in the Brain: Lessons from Insulin-Related Signaling Systems in the Invertebrate Brain.
AB Smit, RE Van Kesteren, KW Li, J van Minnen, S Spijker, H Van Heerikhuizen, and WP Geraerts
Prog Neurobiol 54:35-54 (1998)
Altered Gene Expression in the Host Brain Caused by a Trematode Parasite: Neuropeptide Genes Are Preferentially Affected During Parasitosis.
RM Hoek, RE Van Kesteren, AB Smit, M De Jong-Brink, and WP Geraerts
Proceedings of the National Academy of Sciences, USA 94:14072-14076 (1997)
Co-Evolution of Ligand-Receptor Pairs in the Vasopressin/Oxytocin Superfamily of Bioactive Peptides.
RE Van Kesteren, CP TENSEN, AB Smit, J van Minnen, LF Kolakowski, W MEYERHOF, D Richter, H Van Heerikhuizen, E Vreugdenhil, and WP Geraerts
J Biol Chem 271:3619-3626 (1996)
Structural and Functional Evolution of the Vasopressin/Oxytocin Superfamily: Vasopressin-Related Conopressin Is the Only Member Present in Lymnaea, and Is Involved in the Control of Sexual Behavior.
RE Van Kesteren, AB Smit, RP De Lange, KS KITS, FA Van Golen, RC Van Der Schors, ND de With, JF Burke, and WP Geraerts
J Neurosci 15:5989-5998 (1995)
Co-Localized Neuropeptides Conopressin and Ala-Pro-Gly-Trp-Nh2 Have Antagonistic Effects on the Vas Deferens of Lymnaea.
FA Van Golen, KW Li, RP De Lange, RE Van Kesteren, RC Van Der Schors, and WP Geraerts
Neuroscience 69:1275-1287 (1995)
A Novel G Protein-Coupled Receptor Mediating Both Vasopressin- and Oxytocin-Like Functions of Lys-Conopressin in Lymnaea Stagnalis.
RE Van Kesteren, CP Tensen, AB Smit, J van Minnen, PF van Soest, KS Kits, W Meyerhof, D Richter, H Van Heerikhuizen, and E Vreugdenhil
Neuron 15:897-908 (1995)
Alternative Splicing Generates Diversity of Vd1/Rpd2 Alpha Peptides in the Central Nervous System of Lymnaea Stagnalis.
J Bogerd, RE Van Kesteren, H Van Heerikhuizen, WP Geraerts, J Veenstra, AB Smit, and J Joosse
Cell Mol Neurobiol 13:123-136 (1993)
Evolution of the Vasopressin/Oxytocin Superfamily: Characterization of a Cdna Encoding a Vasopressin-Related Precursor, Preproconopressin, from the Mollusc Lymnaea Stagnalis.
RE Van Kesteren, AB Smit, RW Dirks, ND de With, WP Geraerts, and J Joosse
Proceedings of the National Academy of Sciences, USA 89:4593-4597 (1992)
A Vasopressin-Related Peptide in the Mollusc Lymnaea Stagnalis: Peptide Structure, Prohormone Organization, Evolutionary and Functional Aspects of Lymnaea Conopressin.
RE Van Kesteren, AB Smit, ND de With, J van Minnen, RW Dirks, RC Van Der Schors, and J Joosse
Prog Brain Res 92:47-57 (1992)