Brain disorders caused by mutations in single genes often present unexplained large symptom diversity. The new study shows that non-linear genetic interactions between two or more functionally related genes, STXBP1 and SNAP25, causes extreme phenotypic diversity. The study is published in Molecular Psychiatry.
Networks of nerve cells in our brain process information at high speed. Some cells transfer more than 100 signals per second to the next cell in the circuit by contact points between them, the synapses. Neuroscientists from the CNCR discovered how mobility of molecules on the receiving side of synapses support information processing.
The European Research Council (ERC) awarded neuroscientist Natalia Goriounova a Consolidator Grant for the HumanCircuits project. Goriounova will study neurons in living tissue from the human brain.
The CNCR focuses on the mechanistic understanding of gene function in the context of cognitive function.
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