*PhD position in Neuron-Glia interactions in Alzheimer disease*

*Project description*
We are looking for a candidate for a 4 years PhD project that will be carried out at the CNCR, VU Amsterdam. Recent studies have shown that apart from neurons, glial cells play a major role in synaptic function. As yet, it is unclear to what extent glial cells are also involved in synaptic dysfunction in Alzheimer disease (AD). The overall aim of the project is to obtain insight into the role of glia cells (astrocytes and microglia) in synapse dysfunction at an early stage of AD.
The candidate will be involved in the identification of glial factors that are involved in morphological and functional defects of the synapse in AD. The studies will involve analysis of mouse models and human post mortem tissue, using transgenic, proteomic and imaging techniques. We are looking for a candidate with an interest in molecular and cellular neuroscience. Experience with any of the techniques mentioned is an advantage.

• MSc degree (or equivalent) in biology or biomedical science;
• Research experience in molecular and cellular biology;
• Fluent in English (spoken and written).

*Further particulars*
The initial appointment will be for a period of 1 year. After satisfactory evaluation of the initial appointment, it will be extended for a total duration of 4 years (PhD).

You can find information about our excellent fringe benefits of employment at like:
• remuneration of 8,3% end-of-year bonus and 8% holiday allowance;
• solid pension scheme (ABP);
• a minimum of 29 holidays In case of full-time employment;
• a wide range of sports facilities, which staff may use at a modest charge.

The salary will be in accordance with university regulations for academic personnel, and amounts € 2.222 ,- gross per month in the first year up to € 2.840,- in the fourth year (salary scale 85, PhD) based on a full-time employment.

For additional information please contact:
Dr. M. Verheijen
Phone number +31 (0)20 59 87120

Applicants are requested to write a letter in which they describe their abilities and motivation, accompanied by your curriculum vitae and the names of two scientific referees. Applications should be sent by e-mail before 28 September to:

Brigitte Borgman, VU University Amsterdam
Faculty of Earth and Life Sciences, CNCR
Subject line: Verheijen [vacancy nr, PhD]