A position paper by Verhage & Sorensen published in Neuron on June 19 proposes to unify syndromes caused by mutations in eight core components of the synaptic secretion machinery, based on common etiology and mechanism
The group of Klaus Linkenkaer-Hansen (INF) established a method to estimate excitation/inhibition balance using the theory of critical brain dynamics. By teaming up with the group of Hilgo Bruining (Amsterdam UMC), the method is validated for physiological stratification of autism spectrum disorder.
Arthur-Ervin Avramiea, Richard Hardstone and colleagues from the team of Klaus Linkenkaer-Hansen (INF) publish in eLife that pre-stimulus phase and amplitude regulation of stimulus processing is maximized when neuronal networks operate in the critical state.
PhD student Esther Visser and colleagues in the team of Michel van den Oever (MCN) investigated how alcohol memories are stored in the brain and how this contributes to relapse after prolonged abstinence. Their findings were published in Science Advances.
Alzheimer Nederland awarded a €65 000 fellowship to Lill Eva Johansen for research on the effect of Abca7 mutations associated with Alzheimer’s disease. The work will be performed in human brain cells derived from stem cells that are gene edited using CRISPR technology.
A new study by Miguel Gonzalez-Lozano (MCN) and colleagues demonstrates how cross-linking mass spectrometry can contribute to the discovery of novel synaptic protein interactions. The study was published in Science Advances on February 19, 2020.
The STXBP1 team of FGA obtained funding from the 2019 Million Dollar Bike Ride event, organized by the Orphan Disease Center in the US, for a high throughput screen to identify new therapeutic interventions for STXBP1 patients.
Researchers at CNCR-FGA and two Italian institutes describe the first two patients with a homozygous STXBP1 mutation. Opposite to known mutations, this mutation increases synaptic transmission. The study is published in the leading journal Brain.