Claudia Persoon (CNCR-FGA) and colleagues identified RAB3 and RIM1/2 as essential factors for neuromodulator secretion from dense core vesicles in mammalian neurons. This study is now published in Neuron.
CNCR organized, together with new UMCA professor Hilgo Bruining, a colloquium at the Royal Academy bringing together world leaders to discuss neurodevelopmental disorders and science-based intervention for individual patients.
A study performed by PhD student Vera Wiersma (FGA), from the team of Wiep Scheper, and colleagues reveals that neurons develop granulovacuolar degeneration bodies in response to tau pathology. This collaborative effort was published in Acta Neuropathologica.
A new study by PhD student Sara Hijazi (MCN) shows that reducing the activity of interneurons in the hippocampus restores memory and delays Alzheimer’s disease progression in mice. The study is published in Molecular Psychiatry.
PhD student Kyoko Watanabe (CNCR-CTG) publishes a novel way of using single cell gene expression data to prioritize cell types in disease. Her paper features as Editor’s highlight in Nature Communications
In this study Marinka Brouwer (FGA) shows that adhesion molecule SALM1 binds an intracellular protein complex via one domain and organizes synapse development via another. The study was a collaboration between FGA and MCN.