News FGA

ERC Starting Grant for Amélie Freal

Amélie Freal (FGA) was awarded an ERC Starting Grant by the European Union for the “PLaisTICITY” project to investigate mechanisms underlying Axon Initial Segment plasticity

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ZonMW Dementia Fellowship for Kim de Kleijn

Kim de Kleijn (The Candidate Center/AUMC/FGA) received the ZonMW Dementia Fellowship (3 years) to set-up an independent research line to study the TREM receptor family and its relevance for microglia functioning in context of Alzheimer’s disease.

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VENI grant for Femke Feringa

Femke Feringa (FGA) received a ZonMW VENI grant to develop her independent research line on how the Alzheimer risk mutation APOE4 contributes to senescence (cell aging) in human astrocytes generated from induced pluripotent stem cells.

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CNCR co-hosts 1st European STXBP1 Summit in Milan

The STXBP1 team (FGA) joined 150 other researchers, healthcare professionals, industry representatives, and patient families and -advocates from all over the world for the first European meeting fully dedicated to STXBP1

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Wiep Scheper receives NWO funding to study lysosomal dysfunction

The Dutch Research Council (NWO) has awarded an ENW-M2 open competition grant of 730 k€ to CNCR researcher Wiep Scheper (PI team) to study the role of de-ubiquitinating enzymes in tau-induced dysfunction of the neuronal auto- and endo-lysosomal system. In this multidisciplinary project Scheper PI of the Molecular Neurodegeneration group teams up with ubiquitin signalling expert Aysegul Sapmaz (LUMC, Leiden).

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Optimizing study designs for iPSC-based disease modelling

In a study published in Molecular Psychiatry, Jessie Brunner, Hanna Lammertse and Annemiek van Berkel (FGA) teamed up with Sophie van der Sluis (CTG) and the proteomics facility (MCN) to optimize statistical power for iPSC-based study designs.

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Three CNCR researchers each awarded a VIDI grant

Rik van der Kant, Natalia Goriounova and Priyanka Rao-Ruiz, researchers at the Center for Neurogenomics & Cognitive Research at the Vrije Universiteit Amsterdam, have been awarded by the Dutch Research Council (NWO) with a Vidi grant worth 800,000 euros.

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SFARI director’s award for SYNGO

Guus Smit and Matthijs Verhage obtained funding to coordinate expert annotation of the synaptic protein interactome, with the goal to curate protein-protein interactions implicated in autism.

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CNCR STXBP1 team wins social media challenge

This February, the Orphan Disease Center challenged researchers worldwide to share social media posts about the rare disease they are working on . The three most creative and popular posts were selected as winners on Feb.28th, Rare Disease Day 2022. The CNCR STXBP1 team is one of the winners

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BRAINMODEL: precision medicine for brain disorders

New consortium consisting of researchers from six Dutch knowledge institutions, coordinated by the CNCR and Radboud UMC, has been awarded with a grant of 4 million euros from ZonMW, to develop new research methods to improve treatment for neurodevelopmental disorders.

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How dynamin organizes neuropeptide release sites

Alessandro Moro (CNCR-FGA) and colleagues identified the endocytic protein dynamin as a central regulator for neuromodulator secretion from dense core vesicles in mammalian neurons. This study is now published in Science Advances.

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New study on how calcium triggers neuropeptide secretion

Rhodé van Westen (CNCR-FGA) and colleagues identify Synaptotagmin-1 and Synaptotagmin-7 as redundant calcium sensors for neuromodulator secretion from dense core vesicles in mammalian neurons. This study is published in PNAS on April 28th.

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Chang Zuckerberg Initiative Grant for human Neurolipid atlas

A collaboration between the group of Rik van der Kant (FGA) and Martin Giera (LUMC) has been selected for funding by the Chan Zuckerberg Initiative Neurodegeneration Network. In the first phase of their project, the researchers will receive $150.000 to establish an atlas of the human lipidome in iPSC-derived neurons, astrocytes and microglia in controls and subjects with mutations associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

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Lill Eva Johansen receives Alzheimer Nederland fellowship

Alzheimer Nederland awarded a €65 000 fellowship to Lill Eva Johansen for research on the effect of Abca7 mutations associated with Alzheimer’s disease. The work will be performed in human brain cells derived from stem cells that are gene edited using CRISPR technology.

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CNCR organizes Royal Academy colloquium

CNCR organized, together with new UMCA professor Hilgo Bruining, a colloquium at the Royal Academy bringing together world leaders to discuss neurodevelopmental disorders and science-based intervention for individual patients.

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Novel insight into the biology of granulovacuolar degeneration

A study performed by PhD student Vera Wiersma (FGA), from the team of Wiep Scheper, and colleagues reveals that neurons develop granulovacuolar degeneration bodies in response to tau pathology. This collaborative effort was published in Acta Neuropathologica.

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