In massive GWAS study, PhD student Philip Jansen provides new insight into the genetics of insomnia, published in Nature Genetics

Research team led by Ronald van Kesteren receives 675 k€ to investigate changes in brain activity that can provide new diagnostic markers or treatment targets for early-stage Alzheimer’s disease.

Dr. Rik van der Kant (CNCR-FGA) and colleagues report that accumulation of cholesterol in Alzheimer’s disease neurons drives early Tau- and Amyloid pathology, and can be reversed by cholesterol-targeting drugs. Published in Cell Stem Cell.

Postdocs Iris Jansen, Jeanne Savage and others from CNCR-CTG find novel genetic risk factors for Alzheimer’s dementia, published in Nature Genetics

Natalia Goriounova published the association between large human pyramidal neurons that generate fast action potentials and intelligence in eLIFE

On Saturday the 13th of October the first group of STXBP1-E families came to the VUmc to participate in the new study on STXBP1-Encephalopathy.

Claudia Persoon (CNCR-FGA) & the DCV team published a study on how many secretory vesicles are found in different CNS neurons (this paper is about vesicle pools, not swimming pools!) and how many vesicles fuse upon stimulation. The paper is featured on the cover of EMBO J. this month.

Joshua Obermayer and Tim Heistek publish their study on cholinergic regulation of lateral inhibition in human and mouse cortex in Nature Communications

On Oct. 13, the 1st STXBP1 Patient Clinic Day will take place at VUmc in Amsterdam. The day is part of our studies on STXBP1-Encephalopathy (STXBP1-E) in a collaboration between FGA-CNCR, Clinical Genetics and VU spin-off company NBT Analytics.

PhD student Christiaan de Leeuw (CNCR-CTG) has developed an important new tool for advanced gene-set analyses, published in Nature Communications this week