Ambika Mahajan (FGA) has been awarded the poster prize at the annual meeting of the Dutch Dementia Researchers Conference (DDRC), a national platform aimed at bringing together researchers from all dementia-associated disciplines.
Representing the Molecular Neurodegeneration group, she built on previous findings from the lab showing that astrocytes display stress responses to intraneuronal tau pathology. Using human cellular models, she identified a mechanistic link between increased oxidative stress and the activation of the integrated stress response. She further investigated the physiological consequences for astrocytes.
These results provide new insights into how astrocytes respond and adapt to intraneuronal tau pathology, which could potentially elucidate targets for therapeutic intervention.