A main challenge in genome-wide association studies (GWAS) is to interpret statistical findings in biological context. Post-GWAS annotation facilitates this task yet currently available tools can be time consuming and do not provide integrated visual aids for data interpretation. PhD student Kyoko Watanabe from the Department Complex Trait Genetics developed FUMA: an integrative web-based platform using information from multiple biological resources to facilitate functional annotation of GWAS results, gene prioritization and interactive visualization. The accompanying paper was published this week in Nature Communications.
At the annual meeting of the graduate school Neurosciences Amsterdam and Rotterdam (ONWAR) CNCR members Marieke van Ziel, Vincent Huson, Marinka Brouwer, Claudia Persoon and Mariana Raimundo Pinto de Matos won the Blitz presentation and oral presentation prices.
A study by Marieke Meijer (CNCR-FGA) published in EMBO journal reveals a novel and potent way for neurons to shut down synaptic transmission via tyrosine phosphorylation of Munc18-1.