2016
• Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development Gonzalez-Lozano MA, Klemmer P, Gebuis T, Hassan C, van Nierop P, RE, Smit AB, AB, Li KW. Sci Rep 6, 2016, doi:10. 1038/srep35456
• Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex Pandya NJ, Klaassen RV, van der Schors RC, Slotman JA, Houtsmuller A, Smit AB, Li KW. Proteomics. 2016 Jul 9. doi: 10.1002/pmic.201500400. [Epub ahead of print]
• Functional characterisation of human synaptic genes expressed in the Drosophila brain Zografos L, Tang J, Hesse F, Wanker EE, Li KW, Smit AB, Davies RW, Armstrong JD. Biol Open. 2016 May 15;5(5):662-7. doi: 10.1242/bio.016261.
• Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1 Schmitz SK, King C, Kortleven C, Huson V, Kroon T, Kevenaar JT, Schut D, Saarloos I, Hoetjes JP, de Wit H, Stiedl O, Spijker S, Li KW, Mansvelder HD, Smit AB, Cornelisse LN, Verhage M, Toonen RF. EMBO J. 2016 Jun 1;35(11):1236-50. doi: 10.15252/embj.201592244.
• Impact of genetic variation on synaptic protein levels in genetically diverse mice Loos M, Li KW, van der Schors R, Gouwenberg Y, van der Loo R, Williams RW, Smit AB, Spijker S. Proteomics. 2016 Apr;16(7):1123-30. doi: 10.1002/pmic.201500154.
• Profiling the human hippocampal proteome at all pathologic stages of Alzheimer’s disease Hondius DC, van Nierop P, Li KW, Hoozemans JJ, van der Schors RC, van Haastert ES, van der Vies SM, Rozemuller AJ, Smit AB. Alzheimers Dement. 2016 Jun;12(6):654-68. doi: 10.1016/j.jalz.2015.11.002.
• Proteomic analysis of dynein-interacting proteins in Amyotrophic Lateral Sclerosis synaptosomes reveals alterations in the RNA-binding Protein Staufen1 Gershoni-Emek N, Mazza A, Chein M, Gradus-Pery T, Xiang X, Li KW, Sharan R, Perlson E. Mol Cell Proteomics. 2016 Feb;15(2):506-22. doi: 10.1074/mcp.M115.049965
• Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways Farzana F, Zalm R, Chen N, Li KW, Grant SG, Smit AB, Toonen RF, Verhage M Mol Neurobiol. 2016 May;53(4):2112-23. doi: 10.1007/s12035-015-9164-8
2015
• Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoorms with overlapping interactomes Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen RV, van der Schors RC, Peles E, Verhage M, Smit AB, Li KW. Biochim Biophys Acta. 2015 Jul;1854(7):827-33. doi: 10.1016/j.bbapap.2015.02.008
• FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression Fernández E, Li KW, Rajan N, De Rubeis S, Fiers M, Smit AB, Achsel T, Bagni C. J Neurosci. 2015 Jun 24;35(25):9402-8. doi: 10.1523/JNEUROSCI.4800-14.2015.
• GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome Ferreira JS, Schmidt J, Rio P, Águas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL J Neurosci. 2015 Jun 3;35(22):8462-79. doi: 10.1523/JNEUROSCI.3567-14.2015.
• Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences Giniatullina A, Maroteaux G, Geerts CJ, Koopmans B, Loos M, Klaassen R, Chen N, van der Schors RC, van Nierop P, Li KW, de Jong J, Altrock WD, Cornelisse LN, Toonen RF, van der Sluis S, Sullivan PF, Stiedl O, Posthuma D, Smit AB, Groffen AJ, Verhage M. Neuroscience. 2015 Aug 6;300:518-38. doi: 10.1016/j.neuroscience.2015.05.047.
• Strain differences in presynaptic function: Proteomics, ultrastructure, and physiology of hippocampal synapses in DBA/2J and C57Bl/6J MICE Lenselink AM, Rotaru DC, Li KW, van Nierop P, Rao-Ruiz P, Loos M, van der Schors R, Gouwenberg Y, Wortel J, Mansvelder HD, Smit AB, Spijker S. J Biol Chem. 2015 Jun 19;290(25):15635-45. doi: 10.1074/jbc.M114.628776.
• HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1 Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA,Elgersma Y. Mol Psychiatry. 2015 Nov;20(11):1311-21. doi: 10.1038/mp.2015.48·
• Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic -actin levels Schreiber J, Végh MJ, Dawitz J, Kroon T, Loos M, Labonté D, Li KW, Van Nierop P, Van Diepen MT, De Zeeuw CI, Kneussel M, Meredith RM,Smit AB, Van Kesteren RE . J Cell Biol. 2015 Nov 9;211(3):569-86. doi: 10.1083/jcb.201506048
• A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome Wong KL, Lai YM, Li KW, Lee KF, Ng TB, Cheung HP, Zhang YB, Lao L, Wong RN, Shaw PC, Wong JH, Zhang ZJ, Lam JK, Ye WC, Sze SC. Sci Rep. 2015 Jul 10;5:10179. doi: 10.1038/srep10179.
• Single-cell analysis of peptide expression and electrophysiology of right parietal neurons involved in male copulation behavior of a simultaneous hermaphrodite. El Filali Z, de Boer PA, Pieneman AW, de Lange RP, Jansen RF, Ter Maat A, van der Schors RC, Li KW, van Straalen NM, Koene JM. Invert Neurosci. 2015 Dec;15(4):7. doi: 10.1007/s10158-015-0184-x
2014
• Interaction Proteomics Reveals Brain Region-Specific AMPA Receptor Complexes Chen N, Pandya NJ, Koopmans F, Castelo-Székelv V, van der Schors RC, Smit AB, Li KW. J Proteome Res. 2014 Dec 5;13(12):5695-706. doi: 10.1021/pr500697b
• Proteomic Analysis of Gliosomes from Mouse Brain: Identification and Investigation of Glial Membrane Proteins Carney KE, Milanese M, van Nierop P, Li KW, Oliet SH, Smit AB, Bonanno G, Verheijen MH. J Proteome Res. 2014 Dec 5;13(12):5918-27. doi: 10.1021/pr500829z
• Higher order Arabidopsis 14-3-3 mutants show 14-3-3 involvement in primary root growth both under control and abiotic stress conditions van Kleeff PJ, Jaspert N, Li KW, Rauch S, Oecking C, de Boer AH. J Exp Bot. 2014 Nov;65(20):5877-88. doi: 10.1093/jxb/eru338.
• Light modulated activity of root alkaline/neutral invertase involves the interaction with 14-3-3 proteins Gao J, van Kleeff PJ, Oecking C, Li KW, Erban A, Kopka J, Hincha DK, de Boer AH. Plant J. 2014 Dec;80(5):785-96. doi: 10.1111/tpj.12677.
• Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline Végh MJ, Rausell A, Loos M, Heldring CM, Jurkowski W, van Nierop P, Paliukhovich I, Li KW, del Sol A, Smit AB, Spijker S, van Kesteren RE. Mol Cell Proteomics. 2014 Nov;13(11):2975-85. doi: 10.1074/mcp.M113.032086
• Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease Végh MJ, Heldring CM, Kamphuis W, Hijazi S, Timmerman AJ, Li KW, van Nierop P, Mansvelder HD, Hol EM, Smit AB, van Kesteren RE. Acta Neuropathol Commun. 2014 Jun 29;2:76. doi: 10.1186/s40478-014-0076-z.
• PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG,Kamphorst W, Rozemuller AJ; Netherlands Brain Bank, Bakker EB; International Parkinsonism Genetics Network, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J. Brain. 2014 May;137(Pt 5):1361-73. doi: 10.1093/brain/awu067
• CCHCR1 interacts with EDC4, suggesting its localization in P-bodies Ling YH, Wong CC, Li KW, Chan KM, Boukamp P, Liu WK. Exp Cell Res. 2014 10;327(1):12-23. doi:10.1016 /j.yexcr.2014.05.008
2013
• CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D,Achsel T, Posthuma D, Smit AB, Bagni C. Neuron. 2013 Sep 18;79(6):1169-82. doi: 10.1016/j.
• The glycolytic enzyme Aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment. Sandoval M1, Luarte A, Herrera-Molina R, Varas-Godoy M, Santibáñez M, Rubio FJ, Smit AB, Gundelfinger ED, Li KW, Smalla KH, Wyneken U.. Brain Res. 2013 Jul 3;1520:1-14. doi: 10.1016/j.brainres.2013.04.049
• Interaction proteomics of the AMPA receptor: Towards identification of receptor sub-complexes Li KW, Chen N, Smit AB Amino Acids. 2013 May;44(5):1247-51. doi: 10.1007/s00726-013-1461-9
• Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei Burbach JP, Grant P, Hellemons AJ, Degiorgis JA, Li KW, Pant HC. Biol Open. 2014 Jan 15;3(1):50-8. doi: 10.1242/bio.20136890.
2012
• Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex Li KW, Chen N, Klemmer P, Koopmans F, Karupothula R, Smit AB. Proteomics. 2012 Aug;12(15-16):2428-32. doi: 10.1002/pmic.201100675
• Synapse Associated Protein 102 (SAP102) Binds the C-Terminal Part of the Scaffolding Protein Neurobeachin Lauks J, Klemmer P, Farzana F, Karupothula R, Zalm R, Cooke NE, Li KW, Smit AB, Toonen R, Verhage M. PLoS One. 2012;7(6):e39420. doi: 10.1371/journal.pone.0039420.
• Synaptic Proteome Changes in a DNA Repair Deficient Ercc1 Mouse Model of Accelerated Aging Végh MJ, de Waard MC, van der Pluijm I, Ridwan Y, Sassen MJ, van Nierop P, van der Schors RC, Li KW, Hoeijmakers JH, Smit AB, van Kesteren RE. J Proteome Res. 2012 Mar 2;11(3):1855-67. doi: 10.1021/pr201203m
• Peptide Neurotransmitters and Hormones Ka Wan Li. ELS. Published Online: 17 DEC 2012 DOI: 10.1002/9780470015902.a0000063.pub2
2011
• MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ. Mol Cell Biol. 2011 Sep;31(17):3603-15. doi: 10.1128/MCB.01389-10
• Proteomics, Ultrastructure, and Physiology of Hippocampal Synapses in a Fragile X Syndrome Mouse Model Reveal Presynaptic Phenotype Klemmer P, Meredith RM, Holmgren CD, Klychnikov OI, Stahl-Zeng J, Loos M, van der Schors RC, Wortel J, de Wit H, Spijker S, Rotaru DC, Mansvelder HD,Smit AB, Li KW. J Biol Chem. 2011 Jul 22;286(29):25495-504. doi: 10.1074/jbc.M110.210260
• The Synaptic Proteome during Development and Plasticity of the Mouse Visual Cortex Dahlhaus M, Li KW, van der Schors RC, Saiepour MH, van Nierop P, Heimel JA, Hermans JM, Loos M, Smit AB, Levelt CN. Mol Cell Proteomics. 2011 May;10(5):M110.005413. doi: 10.1074/mcp.M110.005413cs
• Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence Counotte DS, Goriounova NA, Li KW, Loos M, van der Schors RC, Schetters D, Schoffelmeer AN, Smit AB, Mansvelder HD, Pattij T, Spijker S. Nat Neurosci. 2011 Apr;14(4):417-9. doi: 10.1038/nn.2770.
• Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development Counotte DS, Li KW, Wortel J, Gouwenberg Y, Van Der Schors RC, Smit AB, Spijker S. Eur J Neurosci. 2010 Nov;32(9):1452-60. doi: 10.1111/j.1460-9568.2010.07404.
• Neuroproteomics Li KW (ed) Neuromethod 57; Springer
2010
• Gaining efficiency by parallel quantification and identification of iTRAQ-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap Mischerikow N, van Nierop P, Li KW, Bernstein HG, Smit AB, Heck AJ, Altelaar AF. Analyst. 2010 Oct;135(10):2643-52. doi: 10.1039/c0an00267d.
• Extracellular Matrix Plasticity and GABAergic Inhibition of Prefrontal Cortex Pyramidal Cells Facilitates Relapse to Heroin Seeking Van den Oever MC, Lubbers BR, Goriounova NA, Li KW, Van der Schors RC, Loos M, Riga D, Wiskerke J, Binnekade R, Stegeman M, Schoffelmeer AN,Mansvelder HD, Smit AB, De Vries TJ, Spijker S. Neuropsychopharmacology. 2010 Sep;35(10):2120-33. doi: 10.1038/npp.2010.90
• Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated CaV2.1 calcium channels Klychnikov OI, Li KW, Sidorov IA, Loos M, Spijker S, Broos LA, Frants RR, Ferrari MD, Mayboroda OA, Deelder AM, Smit AB, van den Maagdenberg AM Proteomics. 2010 Jul;10(13):2531-5. doi: 10.1002/pmic.200900733.
• Interaction proteomics of synapse protein complexes Li KW, Klemmer P, Smit AB. Anal Bioanal Chem. 2010 Aug;397(8):3195-202. doi: 10.1007/s00216-010-3658-z.
• CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H. Science. 2010 Mar 19;327(5972):1518-22. doi: 10.1126/science.1184178
• Mass Spectrometric Analysis of Molluscan Neuropeptides Li KW, Smit AB. Methods Mol Biol. 2010;615:49-56. doi: 10.1007/978-1-60761-535-4_4.