PoC grant awarded to Karen Laupman and Nathaniel Bell

25 January 2024

PhD candidates Karen Laupman and Nathaniel Bell, with supervisors Associate Professor Vivi Heine and Professor Danielle Posthuma, have been awarded a Proof of Concept (PoC) grant for €55.000 from Amsterdam Neuroscience for their innovative research on repurposing drugs specifically for schizophrenia (SCZ).

Their project aims to explore and validate new therapeutic avenues for SCZ by integrating genome-wide association studies (GWAS) with a unique computational and cellular approach.

This research utilizes induced pluripotent stem cell (iPSC) technology to develop a disease model that reflects the complex genetic landscape of SCZ. The team will analyze transcriptomic and proteomic data from iPSC-derived neural cells to identify disease signatures. These signatures will then guide a drug repurposing pipeline, seeking compounds that can mitigate disease-related transcriptomic and proteomics alterations.

Amsterdam Neuroscience