Douglas Wightman has been awarded by Alzheimer Nederland
Alzheimer Nederland awarded €121,650 to Dr. Douglas Wightman (Complex Trait Genetics) to investigate genetic and environmental prediction of Alzheimer’s disease.
Alzheimer’s disease presents later in life but the biological processes that contribute to the disease development start well before symptom onset. Early prediction of Alzheimer’s disease risk before symptom onset would be beneficial in directing individuals to care earlier and may allow for more effective treatment.
In this project, Douglas will use machine learning methods to combine genetic risk and environmental risk to better predict Alzheimer’s disease. Models of genetic risk will be based on recent large genome wide association studies. There is a specific aim to create a minimal model that limits the number of features for easy clinical implementation.
This research aims to priortise genetic and environmental factors that can accurately