This study provides a statistical evaluation of the core structure inherent to all gene-set analyses. Current implementations in available tools are examined and the factors affecting valid and successful detection of gene sets are described.
Christiaan A. de Leeuw, Benjamin M. Neale, Tom Heskes & Danielle Posthuma. The statistical properties of gene-set analysis
Published online: 12 April 2016 | doi:10.1038/nrg.2016.29