Selected papers:
J. Alam and W. Scheper (2016) Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain. Autophagy in press
Judith M Van Der Harg, Leslie Eggels, Silvie R Ruigrok, Jeroen JM Hoozemans, Susanne E la Fleur, Wiep Scheper (2015) Neuroinflammation is not a prerequisite for diabetes-induced tau phosphorylation Frontiers in neuroscience ;9:432. doi: 10.3389/fnins.2015.00432. eCollection 2015.
W. Scheper and J.J.M. Hoozemans (2015) The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol. 130: 315-31.
J.M. van der Harg, A. Nölle, E.S. van Haastert, A.S. Boerema, R. Zwart, A. M. Strijkstra,J.J.M. Hoozemansand W. Scheper (2014) The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress. Cell Death and Disease 28;5:e1393.
W. Scheper and J.J.M. Hoozemans (2013) A New PERKspective on Neurodegeneration. Sci. Transl. Med. 5, 206fs37
D.A.T. Nijholt, A. Nölle, E.S. van Haastert, H. Edelijn, R.F. Toonen, J.J.M. Hoozemans and W. Scheper (2013) The unfolded protein response activates GSK-3 via selective lysosomal degradation. Neurobiol. Aging. 34:1759-71
B. Le Droumaguet, J. Nicolas, D. Brambilla, A. Maksimenko, E. Salvati, L. De Kimpe, C. Zona, C. Airoldi, M. Gobbi, M. Noiray, M. Canovi, F. Nicotra, W. Scheper,. O. Flores, M. Masserini, K. Andrieux, P. Couvreur (2012) Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. ACS Nano 6: 5866-79
D. Brambilla, R. Verpillot, B. Le Droumaguet, J. Nicolas, M. Taverna, J. Kóňa, S.H. Hashemi, B. Lettiero, L. De Kimpe, M. Gobbi, V. Nicolas, W. Scheper, S.M. Moghimi, I.Tvaroška, P. Couvreur and K. Andrieux (2012) Poly(ethylene glycol) at the Surface of Nanocarriers Alters Aβ Peptide Conformation: Toward a Nanomedicine for Alzheimer’s Disease. ACS Nano 6: 5897-908.
W. Scheper, D.A.T. Nijholt and J.J.M. Hoozemans (2011) The unfolded protein response and proteostasis in Alzheimer disease: Preferential activation of autophagy by endoplasmic reticulum stress. Autophagy. 7(8):910-11.
D.A.T. Nijholt, T.R. de Graaf, E.S. van Haastert, A. Osório Oliveira, C.R. Berkers, R. Zwart, H. Ovaa, F.Baas, J.J.M. Hoozemans and W. Scheper (2011) Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells – implications for Alzheimer’s disease. Cell Death Differ. 18 (6):1071-81.
S.M. Chafekar, J.J.M. Hoozemans, R. Zwart, F. Baas and W. Scheper (2007) Aβ1-42 induces mild endoplasmic reticulum stress in an aggregation state dependent manner. Antioxid. Redox Sign.
J.J.M. Hoozemans, E.S. van Haastert, D.A.T. Nijholt, A.J.M. Rozemuller, P. Eikelenboom and W. Scheper (2009) The Unfolded Protein Response is activated in pretangle neurons in Alzheimer’s disease hippocampus. Am. J. Pathol. 174(4):1241-51.
J.J. Hoozemans, R. Veerhuis, A. Rozemuller, F. Baas, P. Eikelenboom, W. Scheper (2005) The unfolded protein response is activated in Alzheimer’s disease. Acta Neuropathologica, 110:165-72