van Berkel AA, Santos TC, Shaweis H, van Weering JRT, Toonen RF, Verhage M. Loss of MUNC18-1 leads to retrograde transport defects in neurons J Neurochem 2020 Dec 1. doi: 10.1111/jnc.15256. Online ahead of print.
Andre Marreiro, Kristof Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo Rodriguez, Jan R. T. van Weering, Debby Dam, Peter P. Deyn, Adrian Apetri, Liliane Schoofs, Marc H. Mercken. Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived tau fibrils. BMC Molecular and Cell Biology 2020 Nov 12;21(1):81. doi: 10.1186/s12860-020-00320-y.
Vazquez-Sanchez S, Gonzalez-Lozano MA, Walfenzao A, Li KW, van Weering JRT. The endosomal protein sorting nexin 4 is a synaptic protein. Sci Rep. 2020 Oct 26;10(1):18239. doi: 10.1038/s41598-020-74694-6.
Huson V, Meijer M, Dekker R, Ter Veer M, Ruiter M, van Weering JRT, Verhage M, Cornelisse LN
Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1. Elife. 2020 Aug 24;9:e55713. doi: 10.7554/eLife.55713.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, Maritzen T, Haucke V, Raimundo N, Sørensen JB, Milosevic I.
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun. 2020 Mar 9;11(1):1266. doi: 10.1038/s41467-020-14993-8.
Pons-Vizcarra M, Kurps J, Tawfik B, Sørensen, JB, van Weering, JRT and Verhage, M MUNC18-1 regulates submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10. J Cell Sci. 2019 Dec 2;132(23). pii: jcs234674. doi: 10.1242/jcs.234674.
Persoon CM, Hoogstraaten R, van Weering JRT, Kaeser PS, Toonen RF and Verhage M. The Rab3-RIM pathway is essential for neuropeptide release. Neuron. 2019 Dec 18;104(6):1065-1080.e12. doi: 10.1016/j.neuron.2019.09.015.
Wiersma V, van Ziel, AM, Vazquez-Sanchez S, Nolle A, Berenjeno-Correa E, Bonaterra-Pastra A, Clavaguera F, Musters RJP, van Weering JRT, Verhage M, Scheper W. Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology. Acta Neuropathol. 2019 Aug 27. doi: 10.1007/s00401-019-02046-4.
Marinka Brouwer, Fatima Farzana, Frank Koopmans, Ning Chen, Ka Wan Li, Jan R. T. van Weering, August B. Smit, Ruud F. Toonen, & Matthijs Verhage Adhesion molecule SALM1 controls synapse development by promoting F-actin/PIP2 dependent cis-oligomerization of Neurexin. EMBO J Aug 1:e101289. doi: 10.15252/embj.2018101289.
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J.R.T., Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O’Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002.
van Weering JRT, Scheper W. Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet. CNS Drugs. 2019 Jun 4. doi: 10.1007/s40263-019-00643-1.
Ramayanti O, Verkuijlen SAWM, Novianti P, Scheepbouwer C, Misovic B, Koppers-Lalic D, van Weering JRT, Beckers L, Adham M, Martorelli D, Middeldorp JM, Pegtel DM. Vesicle-bound EBV-BART13-3p miRNA in circulation distinguishes nasopharyngeal from other head and neck cancer and asymptomatic EBV-infections. Int J Cancer. 2018 Nov 9. doi: 10.1002/ijc.31967.
Persoon CM, Moro A, Nassal JP, Farina M, Broeke JH, Arora S, Dominguez N, van Weering JRT, Toonen RF, Verhage M. Pool size estimations for dense-core vesicles in mammalian CNS neurons. EMBO J. 2018 Oct 15;37(20). pii: e99672. doi: 10.15252/embj.201899672. Epub 2018 Sep 5.
Emperador-Melero J, Huson V, van Weering JRT, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018 Aug 24;9(1):3421. doi: 10.1038/s41467-018-05699-z.
He E, Lozano MAG, Stringer S, Watanabe K, Sakamoto K, den Oudsten F, Koopmans F, Giamberardino SN, Hammerschlag A, Cornelisse LN, Li KW, van Weering JRT, Posthuma D, Smit AB, Sullivan PF, Verhage M. MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission. Human Molecular Genetics 2018 Jun 1;27(11):1879-1891.
Vazquez-Sanchez S, Bobeldijk S, Dekker MP, van Keimpema L, van Weering JRT. VPS35 depletion does not impair presynaptic structure and function. Sci Rep. 2018 Feb 14;8(1):2996. doi: 10.1038/s41598-018-20448-4.
Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M. Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B. J Neurochem. 2018 Feb;144(3):241-254. doi: 10.1111/jnc.14263. Epub 2017 Dec 27
Meijer M, Dörr B, Lammertse HC, Blithikioti C, van Weering JRT, Toonen RF, Söllner TH, Verhage M. Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly. EMBO J. 2018 Jan 17;37(2):300-320. doi: 10.15252/embj.201796484. Epub 2017 Nov 17.
Geerts, CJ, Mancini, R Chen, N, Koopmans FTW, Li, KW, Smit AB, van Weering, JRT, Verhage, M, Groffen, AJA. Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. PLoS ONE 2017 Jul 26;12(7):e0180912. doi: 10.1371/journal.pone.0180912.
(IF 2.8)
Bugiani M*, Dubey M*, Breur M, Postma NL, Dekker MP, Ter Braak T, Boschert U, Abbink TEM, Mansvelder HD, Min R, van Weering JRT*, van der Knaap MS*. Megalencephalic leukoencephalopathy with cysts: the Glialcam-null mouse model. Ann Clin Transl Neurol. 2017 Jun 6;4(7):450-465. (IF 3.9)
van der Harg JM, van Heest JC, Bangel FN, Patiwael S, van Weering JRT, Scheper W. The UPR reduces glucose metabolism via IRE1 signaling. Biochim Biophys Acta. 2017 Apr;1864(4):655-665. (IF 4.5)
Emperador Melero J, Nadadhur AG, Schut D, van Weering JRT, Heine VM, Toonen RF, Verhage M. Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons. Stem Cell Reports. 2017 Mar 14;8(3):659-672. doi: 10.1016/j.stemcr.2017.01.019. Epub 2017 Feb 23. PMID:28238793
van Eijndhoven MA, Zijlstra JM, Groenewegen NJ, Drees EE, van Niele S, Baglio SR, Koppers-Lalic D, van der Voorn H, Libregts SF, Wauben MH, de Menezes RX, van Weering JRT, Nieuwland R, Visser L, van den Berg A, de Jong D, Pegtel DM. Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients. JCI Insight. 2016 Nov 17;1(19):e89631. (IF not available)
Munch AS*, Kedar GH*, van Weering JRT, Vazquez-Sanchez S, He E, André T, Braun T, Söllner TH,Verhage M, Sørensen JB, Extension of helix 12 in Munc18-1 induces vesicle priming. J Neurosci (2016) Jun 29;36(26):6881-91 (IF 6.4)
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JRT, Broeke JH, Verhage M, Toonen RF. CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.(2015) Elife. Feb 26;4
Kedar GH*, Munch AS*, van Weering JRT, Malsam J, Scheutzow A, de Wit H, Houy S, Tawfik B, Söllner TH, Sørensen JB, Verhage M. A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells. J Neurosci (2015) Oct 21;35(42):14172-82 (IF 6.4)
Brouwer I*, Giniatullina A*, Laurens N, van Weering JRT, Bald D, Wuite GJL*, Groffen AJ*. Direct qunatitative detection of Doc2b-induced hemifusion in optically trapped membranes. Nat Comm. (2015) 6, 8387 (IF 11.6)
Dubey M., Bugiani M., Ridder M.C., Postma N.L., Brouwers E., Polder E., Jacobs J.G., Baayen J.C., Klooster J., Kamermans M., Aardse R., de Kock C.P., Dekker M.P., van Weering J.R.T., Heine V., Abbink T.E., Scheper G.C., Boor I., Lodder J.C., Mansvelder H.D., van der Knaap M.S. Mice with Megalencephalic Leukoencephalopathy with Cysts: A developmental angle. Ann Neurol. 77(1):114-31. (IF 11.9)
Kurps J., Broeke J.H., Cijsouw T., Kompatscher A., van Weering J.R.T.*, de Wit H.*. Quantitative image analysis tool to study the plasma membrane localization of proteins and cortical actin in neuroendocrine cells. J Neurosci Methods. (2014) Oct 30;236:1-10. doi: 10.1016/j.jneumeth.2014.07.022. (IF 1.9)
García-Vallejo J.J., Ilarregui J.M., Kalay H., Chamorro S., Koning N., Unger W.W., Ambrosini M., Montserrat V., Fernandes R.J., Bruijns S.C., van Weering J.R.T., Paauw N.J., O’Toole T., van Horssen J., van der Valk P., Nazmi K., Bolscher J.G., Bajramovic J., Dijkstra C.D., ‘t Hart B.A., van Kooyk Y. CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG. J Exp Med. (2014) Jun 30;211(7):1465-83. (IF 13.9)
Chiasserini D., van Weering J.R.T., Piersma S.R., Pham T.V., Malekzadeh A., Teunissen C.E., de Wit H., Jiménez C.R. Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics. (2014) Jun 25;106:191-204. doi: 10.1016/j.jprot.2014.04.028. (IF 3.9)
Bos E., Hussaarts L., van Weering J.R.T., Ellisman M.H., de Wit H., Koster A.J. Vitrification of Tokuyasu-style immuno-labelled sections for correlative cryo light microscopy and cryo electron tomography. J Struct Biol. (2014) May;186(2):273-82. doi: 10.1016/j.jsb.2014.03.021. (IF 3.4)
van Weering J.R.T., Cullen P.J., Membrane-associated cargo recycling by tubule-based endosomal sorting. Semin Cell Dev Biol. (2014) Jul;31:40-7. doi: 10.1016/j.semcdb.2014.03.015. (IF 5.9)
van Weering, J.R.T., Sessions, R.B., Traer, C.J., Kloer D.P., Bhatia V.K., Stamou D., Hurley, J.H. and Cullen P.J. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J (2012), vol 31(23) pp. 4466-80 (IF 9.3; FFa 7 Recommended)
Brown, E., van Weering, J.R.T., Sharp, T.H., Mantell, J. and Verkade, P. Chapture 10: Capturing Endocytic Segregation Events with HPF-CLEM. Meth Cell Biol (Book series) (2012) vol. 111 pp. 175-201 (IF 1.9)
van Weering, J.R.T., Verkade, P., Cullen, P.J. SNX-BAR-mediated endosome tubulation is coordinated with endosome maturation. Traffic (2012), vol. 13 (1) pp 94-107 (IF 5.3; FFa 6 Recommended)
Harterink M., Port F.*, Lorenowicz M.J.*, McGough I.J.*, Silhankova M., Betist M.C., van Weering J.R.T., van Heesbeen R.G., Middelkoop T.C., Basler K., Cullen P.J. and Korswagen H.C. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol (2011) vol. 13 (8) pp. 914-23 (IF 19.4; FFa 8 Must Read)
van Weering, J.R.T. and Cullen, P.J. News & Views Signaling: Retromer arrests receptor on the run. Nat Chem Biol (2011) vol. 7 (5) pp. 251-2 (IF 15.8)
van Weering, J.R.T.*, Schonn, J.S.*, Mohrmann, R.*, Schlüter, O.M., Südhof, T.C., de Wit, H., Verhage, M., and Sørensen, J.B. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic (2010) vol. 11 (11) pp. 1415-28 (IF 5.3)
van Weering, J.R.T., Brown, E., Sharp, T. H., Mantell, J., Cullen, P.J. and Verkade, P. Chapter 26: Intracellular membrane traffic at high resolution. Meth Cell Biol (Book series) (2010) vol. 96 pp. 619-648 (IF 1.9)
van Weering, J.R.T., Verkade, P. and Cullen, P.J. SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol (2010) vol. 21 (4) pp. 371-80 (IF 5.9)
Wassmer, T., Attar, N., Harterink, M., van Weering, J.R.T., Traer, C.J., Oakley, J., Goud, B., Stephens, D.J., Verkade, P., Korswagen, H.C. and Cullen, P.J. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) vol. 17 (1) pp. 110-22 (IF 13.9)
van Weering J.R.T, Wijntjes, R., de Wit, H., Wortel, J., Cornelisse, L.N., Veldkamp, W.J.H. and Verhage, M. Automated analysis of secretory vesicle distribution at the ultrastructural level. J Neurosci Methods (2008) vol. 173 (1) pp. 83-90 (IF 2.1)
Friedrich, R.*, Groffen, A.J.*, Connell, E., van Weering, J.R.T., Gutman, O., Henis, Y.I., Davletov, B. and Ashery, U. DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci (2008) vol. 28 (27) pp. 6794-806 (IF 7.3)
van Weering, J.R.T., Toonen, R.F. and Verhage, M. The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1. PLoS ONE, 2007; 2:e616. (IF 4.4)
- Authors contibuted equally