Selected peer-reviewed publications
Batenburg KL, Rohde SK, Cornelissen-Steijger P, Breeuwsma N, Heine VM, Scheper W. A Human Neuron/Astrocyte Co-culture to Model Seeded and Spontaneous Intraneuronal Tau Aggregation. Curr Protoc. 2023 Oct;3(10):e900
Batenburg KL, Sestito C, Cornelissen-Steijger P, van Weering JRT, Price LS, Heine VM, Scheper W. A 3D human co-culture to model neuron-astrocyte interactions in tauopathies. Biol Proced Online. 2023 Feb 23;25(1):4
Scheepbouwer C, Aparicio-Puerta E, Gomez-Martin C, Verschueren H, van Eijndhoven M, Wedekind LE, Giannoukakos S, Hijmering N, Gasparotto L, van der Galien HT, van Rijn RS, Aronica E, Kibbelaar R, Heine VM, Wesseling P, Noske DP, Vandertop WP, de Jong D, Pegtel DM, Hackenberg M, Wurdinger T, Gerber A, Koppers-Lalic D. ALL-tRNAseq enables robust tRNA profiling in tissue samples. Genes Dev. 2023 Mar 1;37(5-6):243-257
Dooves S, Kok LML, Holmes DB, Breeuwsma N, Breur M, Bugiani M, Wolf NI, Heine VM. Cortical interneuron development is affected in 4H leukodystrophy. Brain. 2023 Jul 3;146(7):2846-2860
Lucía Castillo Ransanz, Pieter F. J. Van Altena, Vivi M. Heine* and Angelo Accardo* Engineered cell culture microenvironments for mechanobiology studies of brain neural cells. Front. Bioeng. Biotechnol., 14 December 2022 *shared senior authorship.
Hillen AEJ, Leferink PS, Breeuwsma NB, Dooves S, Bergaglio T, Van der Knaap MS, Heine VM. Therapeutic potential of human stem cell transplantations for Vanishing White Matter: A quest for the Goldilocks graft. CNS Neurosci Ther. 2022 Sep;28(9):1315-1325
Hillen AEJ, Hruzova M, Rothgangl T, Breur M, Bugiani M, van der Knaap MS, Schwank G, Heine VM. In vivo targeting of a variant causing vanishing white matter using CRISPR/Cas9. Mol Ther Methods Clin Dev. 2022 Feb 23;25:17-25
Beekhuis-Hoekstra SD, Watanabe K, Werme J, de Leeuw CA, Paliukhovich I, Li KW, Koopmans F, Smit AB, Posthuma D, Heine VM. Systematic assessment of variability in the proteome of iPSC derivatives. Stem Cell Res. 2021 Oct;56:102512
Dooves S, van Velthoven AJH, Suciati LG, Heine VM. Neuron-glia interactions in Tuberous Sclerosis Complex affect the synaptic balance in 2D and organoid cultures. Cells, 2021
Montoro R, Heine VM, Kemp S, Engelen M. Evolution of adrenoleukodystrophy model systems. J Inherit Metab Dis, 2020
Hillen AEJ, Heine VM. Glutamate carrier involvement in mitochondrial dysfunctioning in the brain white matter. Front Mol Biosci, 2020
Drakulic D, Djurovic S, Syed YA, Trattaro S, Caporale N, Falk A, Ofir R, Heine VM, Chawner SJRA, Rodriguez-Moreno A, van den Bree MBM, Testa G, Petrakis S, Harwood AJ. Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD. Mol Autism. 2020 Jun 1;11
Varderidou-Minasian S, Hinz L, Hagemans D, Posthuma D, Altelaar M, Heine VM. Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors. Mol Autism. 2020 May 27;11(1):38
Hinz L, Torrella Barrufet J, Heine VM. KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients. Acta Neuropathol Commun. 2019 Dec 3;7(1):196
Leferink P*, Dooves S*, Hillen A*, Watanabe K, Jacobs G, Gasparotto L, Cornelissen-Steijger P, Van der Knaap MS, Heine VM. Human and mouse iPSC-derived astrocyte subtypes reveal vulnerability in Vanishing White Matter. Ann Neurol, 2019 Nov;86(5):780-792
Dooves S, Leferink PS, Krabbenborg S, Breeuwsma N, Bots S, Hillen A, Jacobs G, Van der Knaap MS, Heine VM. Cell replacement therapy improves pathological hallmarks in a mouse model of leukodystrophy Vanishing White Matter. Stem Cell Reports. 2019 Mar 5;12(3):441-450
Nadadhur AG, Alsaqati M, Gasparotto L, Cornelissen-Steijger P, van Hugte E, Dooves S, Harwood AJ, Heine VM. Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models. Stem Cell Reports. 2019 Jan 8;12(1):42-56.
Hinz L, Hoekstra SD, Watanabe K, Posthuma D, Heine VM. Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders. Stem Cell Rev. 2018 Nov 13.
Nadadhur AG, Leferink PS, Holmes D, Hinz L, Cornelissen-Steijger P, Gasparotto L, Heine VM. Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro. Stem Cell Res. 2018 Oct;32:25-34.
Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM. Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter. Glia. 2018 Apr;66(4):862-873.
Leferink PS & Heine VM.The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine. Am J Pathol. 2017 Oct 10.
Dooves S, Bugiani M, Wisse LE, Abbink TEM, van der Knaap MS, Heine VM.
Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment. Neuropathol Appl Neurobiol. 2017 May 13.
Nadadhur AG, Emperador Melero J, Meijer M, Schut D, Jacobs G, Li KW, Hjorth JJJ, Meredith RM, Toonen RF, Van Kesteren RE, Smit AB, Verhage M, Heine VM. Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells. PLoS One. 2017 Jun 6;12(6):e0178533.
Sabo JK, Heine VM, Silbereis JC, Schirmer L, Levison SW, Rowitch DH. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017 Apr;81(4):560-571.
Emperador Melero J, Nadadhur AG, Schut D, Weering JV, Heine VM, Toonen RF, Verhage M. Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons. Stem Cell Reports. 2017 Mar 14;8(3):659-672.
Holmes DB & Heine VM. Simplified 3D protocol capable of generating early cortical neuroepithelium. Biol Open. 2017 Mar 15;6(3):402-406.
Van der Knaap MS, Wolf NI, Heine VM. Leukodystrophies: Five new things. Neurology: Clinical Practice. Online 2016 Aug 23
Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. Modeling psychiatric disorders: from genomic findings to cellular phenotypes. Mol Psychiatry. 2016 Sep;21(9):1321.
Dooves S, van der Knaap MS, Heine VM. Stem cell therapy for white matter disorders: don’t forget the microenvironment! J Inherit Metab Dis. 2016 Mar 21.
Dooves S, Bugiani M, Postma NL, Polder E, Land N, Horan ST, van Deijk AL, van de Kreeke A, Jacobs G, Vuong C, Klooster J, Kamermans M, Wortel J, Loos M, Wisse LE, Scheper GC, Abbink TE, Heine VM*, van der Knaap MS*. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016 Apr 1;126(4):1512-24. *Shared senior authorship.
Hjorth JJ, Dawitz J, Kroon T, Pires J, Dassen VJ, Berkhout JA, Emperador Melero J, Nadadhur AG, Alevra M, Toonen RF, Heine VM, Mansvelder HD, Meredith RM. Detection of silent cells, synchronization and modulatory activity in developing cellular networks. Dev Neurobiol. 2016 Apr;76(4):357-74.
Dubey M, Bugiani M, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weering JR, Heine VM, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS. Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle. Ann Neurol. 2015 Jan;77(1):114-31
Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 5;81(3):574-87
Heine VM, Dooves S, Holmes D, Wagner J. Induced Pluripotent Stem Cells in Brain Diseases. Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. SpringerBriefs in Neurosciences. 2012, 2012, XV, 59 p. 7 illus., 6 in color.
Heine VM, Griveau A, Chapin C, Ballard PL, Chen JK and Rowitch DH. Small Molecule Smoothened Agonist Prevents Glucocorticoid-induced Neonatal Cerebellar Injury. Science Translational Medicine, 2011 Oct 19;3(105):105ra104
Heine VM, Priller M, Ling J, Rowitch DH, Schüller U. Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. Cancer Research, 2010, 70(13):5220-5.
Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, Ferriero DM. Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain. Neurobiology of Disease, 2010, 41(1):138-46.
Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D’Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature, 2010, 466(7303):253-7.
Heine VM and Rowitch DH. Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. Journal of Clinical Investigation, 2009, 119(2):267-77.
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the USA, 2009, 106(33):14132-7.
Schüller U*, Heine VM*, Mao J, Kho A, Dillon A, Han Y, Huillard E, Sun T, Ligon A, Qian Y, Ma Q, Alvarez-Buylla A, McMahon A, Rowitch DH and Ligon K. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form medulloblastoma. Cancer Cell, 2008, 14(2):123-34. *Shared first authorship.